MLB · Sunday, June 21
Guardians vs Astros Betting Odds – Sunday, June 21
Last game: Sunday, June 21, 2026 · 2:10 PM EDT · Daikin Park, Houston, TX
Odds by Fanduel, updated Oct 9, 2:43 AM ET
- Houston Astros are favored by 1.5 runs at -1900
- Expected total is 8 runs, unchanged from the opening 8
- Astros RP Enyel De Los Santos is Out
Guardians vs Astros odds
Odds by Fanduel, updated Oct 9, 2:43 AM ETBet at Fanduel
How has the line moved?
| Captured | Astros spread | Total |
|---|---|---|
| Mon, Jun 15, 2:10 PM EDT | -1.5 | 8 |
| Wed, Jul 8, 4:41 PM EDT | -1.5 | 8 |
| Fri, Jul 31, 7:12 PM EDT | -1.5 | 8 |
| Sun, Aug 23, 9:44 PM EDT | -1.5 | 8 |
| Wed, Sep 16, 12:15 AM EDT | -1.5 | 8 |
| Fri, Oct 9, 2:46 AM EDT | -1.5 | 8 |
Astros spread
Total (over/under)
Guardians vs Astros team comparison
| Guardians | Astros | |
|---|---|---|
| 85-77 | Record | 81-81 |
| 4.2 | Runs per game | 4.5 |
| 4.1 | Opponent runs/game | 4.7 |
| +0.1 | Run differential | -0.2 |
| 0 | Head-to-head wins | 5 |
Injuries on both sides
| Team | Player | Pos | Status | Injury | Updated |
|---|---|---|---|---|---|
 Guardians | Rhys Hoskins | 1B | Injury reserve | Inflammation | Wed, Oct 7, 8:15 PM EDT |
| Guardians | Colin Holderman | RP | Injury reserve | Surgery | Wed, Oct 7, 8:15 PM EDT |
 Astros | Carlos Correa | SS | Injury reserve | Surgery | Wed, Oct 7, 8:15 PM EDT |
| Astros | Mike Burrows | SP | Injury reserve | Inflammation | Wed, Oct 7, 8:15 PM EDT |
| Astros | Enyel De Los Santos | RP | Out | Tendinitis | Wed, Oct 7, 8:15 PM EDT |
| Astros | Daulton Varsho | CF | Out | Surgery | Wed, Oct 7, 8:15 PM EDT |
| Astros | Cristian Javier | SP | Out | Strain | Wed, Oct 7, 8:15 PM EDT |
| Astros | Brice Matthews | CF | Out | Inflammation | Wed, Oct 7, 8:15 PM EDT |
| Astros | Jake Meyers | CF | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
Consensus Bets on this game
No consensus data yet for Guardians at Astros. Check back closer to game time.
Previous games
Frequently asked questions
Who is favoured in Guardians vs Astros?
Houston Astros were favoured by 1.5 runs (-1.5)
What is the spread for Guardians vs Astros?
Astros -1.5, Guardians +1.5. Opened at -1.5 for Astros
What time is Guardians vs Astros?
No game is currently scheduled
What is Guardians vs Astros head-to-head record?
Guardians 0, Astros 5 in recent games