NFL · Week 6
Cardinals vs Rams Betting Odds – Week 6
Sunday, October 18, 2026 · 4:05 PM EDT · SoFi Stadium, Los Angeles, CA
Odds by Fanduel, updated Oct 9, 2:44 AM ET
- Arizona Cardinals are favored by 0.5 points at -122, Sunday, October 18 at 4:05 PM EDT
- Expected total is 44 points, down from the opening 45
- Cardinals Running Back James Conner is Injury reserve
Cardinals vs Rams odds
Odds by Fanduel, updated Oct 9, 2:44 AM ETBet at Fanduel
How has the line moved?
| Captured | Rams spread | Total |
|---|---|---|
| Wed, Oct 7, 2:48 AM EDT | +2 | 45 |
| Wed, Oct 7, 12:24 PM EDT | +2 | 45 |
| Wed, Oct 7, 10:00 PM EDT | +1 | 44.5 |
| Thu, Oct 8, 7:36 AM EDT | +1 | 44.5 |
| Thu, Oct 8, 5:12 PM EDT | +1 | 44 |
| Fri, Oct 9, 2:48 AM EDT | +0.5 | 44 |
Rams spread
Total (over/under)
Cardinals vs Rams team comparison
| Cardinals | Rams | |
|---|---|---|
| 1-3 | Record | 2-2 |
| 21.8 | Points per game | 21.3 |
| 29.3 | Opponent points/game | 20.8 |
| -7.5 | Points differential | +0.5 |
| 0 | Head-to-head wins | 0 |
Injuries on both sides
| Team | Player | Pos | Status | Injury | Updated |
|---|---|---|---|---|---|
 Cardinals | James Conner | Running Back | Injury reserve | Foot | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Tip Reiman | Tight End | Out 4+ games | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Joey Blount | Safety | Injury reserve | Neck | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Zachary Carter | Defensive Tackle | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Kaleb Proctor | Defensive Tackle | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Chase Bisontis | Guard | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Trey Benson | Running Back | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Jameson Geers | Tight End | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Dadrion Taylor-Demerson | Safety | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Isaiah Adams | Guard | May play | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Garrett Williams | Cornerback | May play | Achilles | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Carson Beck | Quarterback | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Andrew Billings | Defensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Reggie Virgil | Wide Receiver | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Kitan Crawford | Safety | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Jack Gibbens | Linebacker | May play | Shoulder | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Roy Lopez | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Max Melton | Cornerback | May play | Toe | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Isaac Seumalo | Guard | May play | Shoulder | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Cody Simon | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Josh Fryar | Offensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Will Johnson | Cornerback | Injury reserve | Neck | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Hjalte Froholdt | Center | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Walter Nolen III | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Mack Wilson Sr. | Linebacker | May play | Thumb | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Josh Sweat | Linebacker | May play | Groin | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Cameron Robertson | Linebacker | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Starling Thomas V | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Andrew Wingard | Safety | May play | Knee | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Hunter Long | Tight End | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Paris Johnson Jr. | Offensive Tackle | Injury reserve | Biceps | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Jeremiyah Love | Running Back | May play | Ankle | Wed, Oct 7, 8:15 PM EDT |
 Rams | Justin Dedich | Guard | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Rams | Eddie Walls III | Linebacker | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Rams | Matthew Caldwell | Quarterback | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Rams | Daniel Rickert | Defensive End | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Rams | Keir Thomas II | Linebacker | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| Rams | Keagen Trost | Offensive Tackle | Injury reserve | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Rams | Tutu Atwell | Wide Receiver | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Rams | CJ Daniels | Wide Receiver | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Rams | Max Klare | Tight End | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| Rams | Bill Murray | Guard | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Rams | Ty Simpson | Quarterback | Not playing | Back | Wed, Oct 7, 8:15 PM EDT |
| Rams | Davis Allen | Tight End | May play | Concussion | Wed, Oct 7, 8:15 PM EDT |
| Rams | Kam Curl | Safety | May play | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Rams | Myles Garrett | Defensive End | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Rams | Nate Landman | Linebacker | May play | Shoulder | Wed, Oct 7, 8:15 PM EDT |
| Rams | Omar Speights | Linebacker | May play | Hip | Wed, Oct 7, 8:15 PM EDT |
| Rams | Kamren Kinchens | Safety | May play | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Rams | Puka Nacua | Wide Receiver | May play | Hip | Wed, Oct 7, 8:15 PM EDT |
| Rams | Jordan Whittington | Wide Receiver | May play | Quadriceps | Wed, Oct 7, 8:15 PM EDT |
| Rams | Ronnie Rivers | Running Back | Injury reserve | Calf | Wed, Oct 7, 8:15 PM EDT |
| Rams | Terrance Ferguson | Tight End | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Rams | Alaric Jackson | Offensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Rams | Colby Parkinson | Tight End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Rams | Maximus Pulley | Safety | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Rams | Jaylen Watson | Cornerback | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Rams | Aaron Donald | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Rams | Josh Wallace | Cornerback | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Rams | Josaiah Stewart | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Rams | Cam Lampkin | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Rams | Konata Mumpfield | Wide Receiver | May play | Rotator cuff | Wed, Oct 7, 8:15 PM EDT |
Consensus Bets on this game
No consensus data yet for Cardinals at Rams. Check back closer to game time.
Frequently asked questions
Who is favoured in Cardinals vs Rams on Sunday, October 18?
Arizona Cardinals are favoured by 0.5 points (-0.5)
What is the spread for Cardinals vs Rams on Sunday, October 18?
Rams +0.5, Cardinals -0.5. Opened at +2 for Rams
What time is Cardinals vs Rams on Sunday, October 18?
Sunday, October 18, 2026 at 4:05 PM EDT, SoFi Stadium, Los Angeles, CA
What is Cardinals vs Rams head-to-head record?
Cardinals 0, Rams 0 in recent games