NFL · Week 6
Commanders vs 49ers Betting Odds – Week 6
Monday, October 19, 2026 · 8:15 PM EDT · Levi's Stadium, San Francisco, CA
Odds by Fanduel, updated Oct 9, 2:26 AM ET
Week 6
Monday, October 19
8:15 PM EDT
@ Levi's Stadium, San Francisco, CA
- Washington Commanders are favored by 2.5 points at -255, Monday, October 19 at 8:15 PM EDT
- Expected total is 44 points, up from the opening 43.5
- 49ers Fullback Kyle Juszczyk is Out
Commanders vs 49ers odds
Odds by Fanduel, updated Oct 9, 2:26 AM ETBet at Fanduel
How has the line moved?
| Captured | 49ers spread | Total |
|---|---|---|
| Wed, Oct 7, 2:32 AM EDT | +3 | 43.5 |
| Wed, Oct 7, 12:08 PM EDT | +3 | 44 |
| Wed, Oct 7, 9:44 PM EDT | +2.5 | 43.5 |
| Thu, Oct 8, 7:20 AM EDT | +2.5 | 43.5 |
| Thu, Oct 8, 4:56 PM EDT | +2.5 | 44 |
| Fri, Oct 9, 2:32 AM EDT | +2.5 | 44 |
49ers spread
Total (over/under)
Commanders vs 49ers team comparison
| Commanders | 49ers | |
|---|---|---|
| 1-3 | Record | 4-0 |
| 22.0 | Points per game | 30.5 |
| 30.5 | Opponent points/game | 16.0 |
| -8.5 | Points differential | +14.5 |
| 0 | Head-to-head wins | 0 |
Injuries on both sides
| Team | Player | Pos | Status | Injury | Updated |
|---|---|---|---|---|---|
 Commanders | Deatrich Wise Jr. | Defensive End | Out 4+ games | Quadriceps | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Trey Amos | Cornerback | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Jeremy McNichols | Running Back | Injury reserve | Quadriceps | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Laremy Tunsil | Offensive Tackle | Injury reserve | Triceps | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Dorance Armstrong | Defensive End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Jer'Zhan Newton | Defensive Tackle | Injury reserve | Pectoral | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Ricky Barber | Defensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Treylon Burks | Wide Receiver | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Athan Kaliakmanis | Quarterback | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Luke McCaffrey | Wide Receiver | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Tanoa Togiai | Guard | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Frankie Luvu | Linebacker | May play | Groin | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Chig Okonkwo | Tight End | May play | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Jordan Magee | Linebacker | Injury reserve | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Tyler Owens | Safety | May play | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Commanders | K'Lavon Chaisson | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Jaylin Lane | Wide Receiver | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Charles Omenihu | Defensive End | May play | Groin | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Odafe Oweh | Linebacker | May play | Calf | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Daron Payne | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Javon Kinlaw | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Isaac Yiadom | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Jayden Daniels | Quarterback | May play | Elbow | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Brandon Coleman | Guard | May play | Finger | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Sam Cosmi | Guard | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Nick Cross | Safety | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Kaytron Allen | Running Back | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Percy Butler | Safety | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Leo Chenal | Linebacker | Injury reserve | Neck | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Jeremy Reaves | Safety | May play | Finger | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Javontae Jean-Baptiste | Linebacker | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Rachaad White | Running Back | May play | Shoulder | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Nick Allegretti | Guard | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Lucas Patrick | Guard | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Amik Robertson | Cornerback | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Ben Sinnott | Tight End | May play | Ribs | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Terry McLaurin | Wide Receiver | May play | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Marcus Mariota | Quarterback | Likely out | Knee | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Stefon Diggs | Wide Receiver | May play | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Jacory Croskey-Merritt | Running Back | May play | Groin | Wed, Oct 7, 8:15 PM EDT |
| Commanders | Sonny Styles | Linebacker | May play | Groin | Wed, Oct 7, 8:15 PM EDT |
 49ers | Isaac Guerendo | Running Back | Out 4+ games | Pectoral | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Brandon Aiyuk | Wide Receiver | Reserve | Head | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Christian Kirk | Wide Receiver | Injury reserve | Calf | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Mykel Williams | Defensive End | Out 4+ games | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Ricky Pearsall | Wide Receiver | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Andrew Farmer II | Defensive End | Injury reserve | Back | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Darrick Forrest | Safety | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Mikail Kamara | Defensive End | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Sam Okuayinonu | Defensive Tackle | Injury reserve | Foot | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Brett Toth | Center | Injury reserve | Concussion | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Nate Hobbs | Cornerback | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Nick Martin | Linebacker | Injury reserve | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Austen Pleasants | Offensive Tackle | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Nick Zakelj | Offensive Tackle | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Alfred Collins | Defensive Tackle | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Tatum Bethune | Linebacker | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Enrique Cruz Jr. | Offensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jordan James | Running Back | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Ephesians Prysock | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Kurtis Rourke | Quarterback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jordan Watkins | Wide Receiver | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| 49ers | De'Zhaun Stribling | Wide Receiver | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jake Tonges | Tight End | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Kyle Juszczyk | Fullback | Out | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Khalid Kareem | Defensive End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| 49ers | George Kittle | Tight End | May play | Achilles | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Eddy Pineiro | Place Kicker | May play | Illness | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Keion White | Defensive End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Kaelon Black | Running Back | May play | Illness | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Romello Height | Defensive End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jack Jones | Cornerback | May play | Foot | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Demarcus Robinson | Wide Receiver | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Mike Evans | Wide Receiver | May play | Ribs | Wed, Oct 7, 8:15 PM EDT |
| 49ers | James Thompson Jr. | Defensive Tackle | Likely out | doubtful | Wed, Oct 7, 8:15 PM EDT |
| 49ers | C.J. West | Defensive Tackle | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Nick Bosa | Defensive End | Likely out | doubtful | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Dre Greenlaw | Linebacker | May play | Quadriceps | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Gracen Halton | Defensive Tackle | May play | Ankle | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Trent Williams | Offensive Tackle | May play | Neck | Wed, Oct 7, 8:15 PM EDT |
| 49ers | KhaDarel Hodge | Wide Receiver | May play | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jaden Dugger | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Marques Sigle | Safety | Out | out | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Upton Stout | Cornerback | May play | Shoulder | Wed, Oct 7, 8:15 PM EDT |
Consensus Bets on this game
No consensus data yet for Commanders at 49ers. Check back closer to game time.
Frequently asked questions
Who is favoured in Commanders vs 49ers on Monday, October 19?
Washington Commanders are favoured by 2.5 points (-2.5)
What is the spread for Commanders vs 49ers on Monday, October 19?
49ers +2.5, Commanders -2.5. Opened at +3 for 49ers
What time is Commanders vs 49ers on Monday, October 19?
Monday, October 19, 2026 at 8:15 PM EDT, Levi's Stadium, San Francisco, CA
What is Commanders vs 49ers head-to-head record?
Commanders 0, 49ers 0 in recent games