NFL · 2026

San Francisco 49ers

2nd NFC West · 4-0

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49ers Away4-0

Week 5

Sunday, October 11

4:25 PM EDT

@ Lumen Field, Seattle, WA

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Seahawks Home3-1

Odds by Fanduel, updated Oct 9, 1:34 AM ET

Next game moneyline

+151

@ Seahawks

Win division

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Win Super Bowl

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Consensus Bets on this game

2 sources weighed in

Full board

Seattle Seahawks2/2 (100%)

Covers favors Seattle, pointing to the Seahawks' 6-0 ATS record against winning teams and a perfect 4-0 ATS mark in their last four games against NFC West opponents.

100% of tracked sources lean toward Seattle Seahawks. This means most of the 19 outlets BettingLadies tracks expect Seattle Seahawks to win, though the split can shift as game time approaches.

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49ers injury report

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Injury report
Player	Pos	Status	Injury	Updated
Isaac Guerendo	Running Back	Out 4+ games	Pectoral	Wed, Oct 7, 8:15 PM EDT
Brandon Aiyuk	Wide Receiver	Reserve	Head	Wed, Oct 7, 8:15 PM EDT
Christian Kirk	Wide Receiver	Injury reserve	Calf	Wed, Oct 7, 8:15 PM EDT
Mykel Williams	Defensive End	Out 4+ games	Knee	Wed, Oct 7, 8:15 PM EDT
Ricky Pearsall	Wide Receiver	Injury reserve	Knee	Wed, Oct 7, 8:15 PM EDT

San Francisco 49ers schedule and results

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San Francisco 49ers schedule
Date	Opponent	Venue	Line	Total	Result
Thu, Sep 10Week 1	@Rams	Melbourne Cricket Ground, Los Angeles, CA	SF -0.5	43.5	W 27-7
Sun, Sep 20Week 2	vsDolphins	Levi's Stadium, San Francisco, CA	SF +3.5	45	W 35-13
Sun, Sep 27Week 3	vsCardinals	Levi's Stadium, San Francisco, CA	SF -0.5	44.5	W 36-30
Sun, Oct 4Week 4	vsBroncos	Levi's Stadium, San Francisco, CA	SF +1	43	W 24-14
Sun, Oct 11Week 5	@Seahawks	Lumen Field, Seattle, WA	SF +1.5	46.5	4:25 PM EDT	Preview
Mon, Oct 19Week 6	vsCommanders	Levi's Stadium, San Francisco, CA	SF +2.5	44	8:15 PM EDT	Preview
Sun, Oct 25Week 7	@Falcons	Mercedes-Benz Stadium, Atlanta, GA	SF +5	45.5	1:00 PM EDT	Preview
Sun, Nov 8Week 9	vsRaiders	Levi's Stadium, San Francisco, CA	SF +4	46.5	4:05 PM EST	Preview
Sun, Nov 15Week 10	@Cowboys	AT&T Stadium, Dallas, TX	SF +1	45	4:25 PM EST	Preview
Sun, Nov 22Week 11	vsVikings	Estadio Banorte, San Francisco, CA	SF +3	45.5	8:20 PM EST	Preview
Sun, Nov 29Week 12	vsSeahawks	Levi's Stadium, San Francisco, CA	SF +0.5	43.5	4:25 PM EST	Preview
Sun, Dec 6Week 13	@Giants	MetLife Stadium, New York, NJ	SF +1	47.5	1:00 PM EST	Preview
Sun, Dec 13Week 14	vsRams	Levi's Stadium, San Francisco, CA	SF -1.5	46.5	4:25 PM EST	Preview
Thu, Dec 17Week 15	@Chargers	SoFi Stadium, Los Angeles, CA	SF +3	44.5	8:15 PM EST	Preview
Sun, Dec 27Week 16	@Chiefs	Arrowhead Stadium, Kansas City, MO	SF -1	48	4:25 PM EST	Preview
Sun, Jan 3Week 17	vsEagles	Levi's Stadium, San Francisco, CA	SF -2.5	44	8:20 PM EST	Preview
Sun, Jan 10Week 18	@Cardinals	State Farm Stadium, Arizona, AZ	SF +0.5	45.5	12:00 AM EST	Preview