NFL · Week 14
Rams vs 49ers Betting Odds – Week 14
Sunday, December 13, 2026 · 4:25 PM EST · Levi's Stadium, San Francisco, CA
Odds by Fanduel, updated Oct 9, 2:38 AM ET
- San Francisco 49ers are favored by 1.5 points at -174, Sunday, December 13 at 4:25 PM EST
- Expected total is 46.5 points, up from the opening 46
- 49ers Fullback Kyle Juszczyk is Out
Rams vs 49ers odds
Odds by Fanduel, updated Oct 9, 2:38 AM ETBet at Fanduel
How has the line moved?
| Captured | 49ers spread | Total |
|---|---|---|
| Wed, Oct 7, 2:44 AM EDT | -1.5 | 46 |
| Wed, Oct 7, 12:20 PM EDT | -1.5 | 46.5 |
| Wed, Oct 7, 9:56 PM EDT | -1.5 | 46 |
| Thu, Oct 8, 7:32 AM EDT | -1.5 | 46 |
| Thu, Oct 8, 5:08 PM EDT | -1.5 | 46 |
| Fri, Oct 9, 2:44 AM EDT | -1.5 | 46.5 |
49ers spread
Total (over/under)
Rams vs 49ers team comparison
| Rams | 49ers | |
|---|---|---|
| 2-2 | Record | 4-0 |
| 21.3 | Points per game | 30.5 |
| 20.8 | Opponent points/game | 16.0 |
| +0.5 | Points differential | +14.5 |
| 0 | Head-to-head wins | 1 |
Injuries on both sides
| Team | Player | Pos | Status | Injury | Updated |
|---|---|---|---|---|---|
 Rams | Justin Dedich | Guard | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Rams | Eddie Walls III | Linebacker | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Rams | Matthew Caldwell | Quarterback | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Rams | Daniel Rickert | Defensive End | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Rams | Keir Thomas II | Linebacker | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| Rams | Keagen Trost | Offensive Tackle | Injury reserve | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Rams | Tutu Atwell | Wide Receiver | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Rams | CJ Daniels | Wide Receiver | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Rams | Max Klare | Tight End | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| Rams | Bill Murray | Guard | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Rams | Ty Simpson | Quarterback | Not playing | Back | Wed, Oct 7, 8:15 PM EDT |
| Rams | Davis Allen | Tight End | May play | Concussion | Wed, Oct 7, 8:15 PM EDT |
| Rams | Kam Curl | Safety | May play | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Rams | Myles Garrett | Defensive End | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Rams | Nate Landman | Linebacker | May play | Shoulder | Wed, Oct 7, 8:15 PM EDT |
| Rams | Omar Speights | Linebacker | May play | Hip | Wed, Oct 7, 8:15 PM EDT |
| Rams | Kamren Kinchens | Safety | May play | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Rams | Puka Nacua | Wide Receiver | May play | Hip | Wed, Oct 7, 8:15 PM EDT |
| Rams | Jordan Whittington | Wide Receiver | May play | Quadriceps | Wed, Oct 7, 8:15 PM EDT |
| Rams | Ronnie Rivers | Running Back | Injury reserve | Calf | Wed, Oct 7, 8:15 PM EDT |
| Rams | Terrance Ferguson | Tight End | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Rams | Alaric Jackson | Offensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Rams | Colby Parkinson | Tight End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Rams | Maximus Pulley | Safety | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Rams | Jaylen Watson | Cornerback | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Rams | Aaron Donald | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Rams | Josh Wallace | Cornerback | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Rams | Josaiah Stewart | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Rams | Cam Lampkin | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Rams | Konata Mumpfield | Wide Receiver | May play | Rotator cuff | Wed, Oct 7, 8:15 PM EDT |
 49ers | Isaac Guerendo | Running Back | Out 4+ games | Pectoral | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Brandon Aiyuk | Wide Receiver | Reserve | Head | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Christian Kirk | Wide Receiver | Injury reserve | Calf | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Mykel Williams | Defensive End | Out 4+ games | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Ricky Pearsall | Wide Receiver | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Andrew Farmer II | Defensive End | Injury reserve | Back | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Darrick Forrest | Safety | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Mikail Kamara | Defensive End | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Sam Okuayinonu | Defensive Tackle | Injury reserve | Foot | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Brett Toth | Center | Injury reserve | Concussion | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Nate Hobbs | Cornerback | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Nick Martin | Linebacker | Injury reserve | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Austen Pleasants | Offensive Tackle | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Nick Zakelj | Offensive Tackle | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Alfred Collins | Defensive Tackle | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Tatum Bethune | Linebacker | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Enrique Cruz Jr. | Offensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jordan James | Running Back | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Ephesians Prysock | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Kurtis Rourke | Quarterback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jordan Watkins | Wide Receiver | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| 49ers | De'Zhaun Stribling | Wide Receiver | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jake Tonges | Tight End | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Kyle Juszczyk | Fullback | Out | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Khalid Kareem | Defensive End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| 49ers | George Kittle | Tight End | May play | Achilles | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Eddy Pineiro | Place Kicker | May play | Illness | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Keion White | Defensive End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Kaelon Black | Running Back | May play | Illness | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Romello Height | Defensive End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jack Jones | Cornerback | May play | Foot | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Demarcus Robinson | Wide Receiver | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Mike Evans | Wide Receiver | May play | Ribs | Wed, Oct 7, 8:15 PM EDT |
| 49ers | James Thompson Jr. | Defensive Tackle | Likely out | doubtful | Wed, Oct 7, 8:15 PM EDT |
| 49ers | C.J. West | Defensive Tackle | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Nick Bosa | Defensive End | Likely out | doubtful | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Dre Greenlaw | Linebacker | May play | Quadriceps | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Gracen Halton | Defensive Tackle | May play | Ankle | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Trent Williams | Offensive Tackle | May play | Neck | Wed, Oct 7, 8:15 PM EDT |
| 49ers | KhaDarel Hodge | Wide Receiver | May play | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jaden Dugger | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Marques Sigle | Safety | Out | out | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Upton Stout | Cornerback | May play | Shoulder | Wed, Oct 7, 8:15 PM EDT |
Consensus Bets on this game
No consensus data yet for Rams at 49ers. Check back closer to game time.
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Frequently asked questions
Who is favoured in Rams vs 49ers on Sunday, December 13?
San Francisco 49ers are favoured by 1.5 points (-1.5)
What is the spread for Rams vs 49ers on Sunday, December 13?
49ers -1.5, Rams +1.5. Opened at -1.5 for 49ers
What time is Rams vs 49ers on Sunday, December 13?
Sunday, December 13, 2026 at 4:25 PM EST, Levi's Stadium, San Francisco, CA
What is Rams vs 49ers head-to-head record?
Rams 0, 49ers 1 in recent games