NFL · 2026
San Francisco 49ers
2nd NFC West · 4-0
San Francisco 49ers injury report
Showing 43 of 43 players
| Player | Pos | Status | Injury | Updated |
|---|---|---|---|---|
| Isaac Guerendo | Running Back | Out 4+ games | Pectoral | Wed, Oct 7, 8:15 PM EDT |
| Brandon Aiyuk | Wide Receiver | Reserve | Head | Wed, Oct 7, 8:15 PM EDT |
| Christian Kirk | Wide Receiver | Injury reserve | Calf | Wed, Oct 7, 8:15 PM EDT |
| Mykel Williams | Defensive End | Out 4+ games | Knee | Wed, Oct 7, 8:15 PM EDT |
| Ricky Pearsall | Wide Receiver | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Andrew Farmer II | Defensive End | Injury reserve | Back | Wed, Oct 7, 8:15 PM EDT |
| Darrick Forrest | Safety | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Mikail Kamara | Defensive End | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Sam Okuayinonu | Defensive Tackle | Injury reserve | Foot | Wed, Oct 7, 8:15 PM EDT |
| Brett Toth | Center | Injury reserve | Concussion | Wed, Oct 7, 8:15 PM EDT |
| Nate Hobbs | Cornerback | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| Nick Martin | Linebacker | Injury reserve | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Austen Pleasants | Offensive Tackle | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Nick Zakelj | Offensive Tackle | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Alfred Collins | Defensive Tackle | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Tatum Bethune | Linebacker | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Enrique Cruz Jr. | Offensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Jordan James | Running Back | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| Ephesians Prysock | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Kurtis Rourke | Quarterback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Jordan Watkins | Wide Receiver | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| De'Zhaun Stribling | Wide Receiver | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Jake Tonges | Tight End | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Kyle Juszczyk | Fullback | Out | Knee | Wed, Oct 7, 8:15 PM EDT |
| Khalid Kareem | Defensive End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| George Kittle | Tight End | May play | Achilles | Wed, Oct 7, 8:15 PM EDT |
| Eddy Pineiro | Place Kicker | May play | Illness | Wed, Oct 7, 8:15 PM EDT |
| Keion White | Defensive End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Kaelon Black | Running Back | May play | Illness | Wed, Oct 7, 8:15 PM EDT |
| Romello Height | Defensive End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Jack Jones | Cornerback | May play | Foot | Wed, Oct 7, 8:15 PM EDT |
| Demarcus Robinson | Wide Receiver | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Mike Evans | Wide Receiver | May play | Ribs | Wed, Oct 7, 8:15 PM EDT |
| James Thompson Jr. | Defensive Tackle | Likely out | doubtful | Wed, Oct 7, 8:15 PM EDT |
| C.J. West | Defensive Tackle | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Nick Bosa | Defensive End | Likely out | doubtful | Wed, Oct 7, 8:15 PM EDT |
| Dre Greenlaw | Linebacker | May play | Quadriceps | Wed, Oct 7, 8:15 PM EDT |
| Gracen Halton | Defensive Tackle | May play | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Trent Williams | Offensive Tackle | May play | Neck | Wed, Oct 7, 8:15 PM EDT |
| KhaDarel Hodge | Wide Receiver | May play | Knee | Wed, Oct 7, 8:15 PM EDT |
| Jaden Dugger | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Marques Sigle | Safety | Out | out | Wed, Oct 7, 8:15 PM EDT |
| Upton Stout | Cornerback | May play | Shoulder | Wed, Oct 7, 8:15 PM EDT |
League-wide report: NFL injuries. 
49ers