NFL · Week 3
Chargers vs Bills Betting Odds – Week 3
Last game: Sunday, September 27, 2026 · 1:00 PM EDT · Highmark Stadium, Buffalo, NY
Odds by Fanduel, updated Oct 9, 2:42 AM ET
Week 3
Sunday, September 27
1:00 PM EDT
@ Highmark Stadium, Buffalo, NY
Final: Chargers 16, Bills 24
- Buffalo Bills are favored by 1.5 points at -175
- Expected total is 47 points, up from the opening 45.5
- Chargers Offensive Tackle Rashawn Slater is Out
Chargers vs Bills odds
Odds by Fanduel, updated Oct 9, 2:42 AM ETBet at Fanduel
How has the line moved?
| Captured | Bills spread | Total |
|---|---|---|
| Mon, Sep 21, 1:00 PM EDT | -0.5 | 45.5 |
| Fri, Sep 25, 1:21 AM EDT | -1 | 45.5 |
| Mon, Sep 28, 1:43 PM EDT | -1 | 46 |
| Fri, Oct 2, 2:04 AM EDT | -1 | 46.5 |
| Mon, Oct 5, 2:26 PM EDT | -1.5 | 46.5 |
| Fri, Oct 9, 2:48 AM EDT | -1.5 | 47 |
Bills spread
Total (over/under)
Chargers vs Bills team comparison
| Chargers | Bills | |
|---|---|---|
| 0-4 | Record | 3-1 |
| 16.8 | Points per game | 31.8 |
| 26.5 | Opponent points/game | 26.8 |
| -9.8 | Points differential | +5.0 |
| 0 | Head-to-head wins | 1 |
Injuries on both sides
| Team | Player | Pos | Status | Injury | Updated |
|---|---|---|---|---|---|
 Chargers | Isaiah World | Offensive Tackle | Out 4+ games | nfi-r | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Tyler Biadasz | Center | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Scott Matlock | Fullback | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Denzel Perryman | Linebacker | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Branson Taylor | Guard | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Deane Leonard | Cornerback | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Alex Harkey | Guard | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Chargers | RJ Mickens | Safety | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Trevor Penning | Guard | May play | Head | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Logan Taylor | Guard | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Ladd McConkey | Wide Receiver | May play | Foot | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Elijah Molden | Cornerback | May play | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Chargers | KeAndre Lambert-Smith | Wide Receiver | Injury reserve | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Derius Davis | Wide Receiver | May play | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Trey Pipkins III | Offensive Tackle | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Teair Tart | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Dalvin Tomlinson | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Isas Waxter | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Derwin James Jr. | Safety | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | David Njoku | Tight End | Injury reserve | Fibula | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Kayode Awosika | Guard | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Charlie Kolar | Tight End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Brenen Thompson | Wide Receiver | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Rodney Shelley | Cornerback | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Rashawn Slater | Offensive Tackle | Out | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Cole Strange | Guard | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Tuli Tuipulotu | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Trey Lance | Quarterback | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | DJ Uiagalelei | Quarterback | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Donte Jackson | Cornerback | May play | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Justin Eboigbe | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Keaton Mitchell | Running Back | May play | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Joe Alt | Offensive Tackle | May play | Neck | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Quentin Johnston | Wide Receiver | May play | Johnston was limited at Wednes… | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Cam Hart | Cornerback | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Alec Ingold | Fullback | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
 Bills | Tyrell Shavers | Wide Receiver | Out 4+ games | out | Wed, Oct 7, 8:15 PM EDT |
| Bills | Dorian Strong | Cornerback | Out 4+ games | nfi-r | Wed, Oct 7, 8:15 PM EDT |
| Bills | Ty Johnson | Running Back | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Bills | Phidarian Mathis | Defensive Tackle | Suspended | reserve-sus | Wed, Oct 7, 8:15 PM EDT |
| Bills | Zane Durant | Defensive Tackle | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| Bills | T.J. Sanders | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Bills | Skyler Bell | Wide Receiver | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Bills | Jude Bowry | Offensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Bills | Mike Danna | Defensive End | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Bills | Jalon Kilgore | Safety | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Bills | Ar'maj Reed-Adams | Guard | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Bills | Terrel Bernard | Linebacker | May play | Calf | Wed, Oct 7, 8:15 PM EDT |
| Bills | Cole Bishop | Safety | May play | Groin | Wed, Oct 7, 8:15 PM EDT |
| Bills | Ed Oliver | Defensive Tackle | May play | Knee | Wed, Oct 7, 8:15 PM EDT |
| Bills | DJ Moore | Wide Receiver | May play | Shoulder | Wed, Oct 7, 8:15 PM EDT |
| Bills | Keon Coleman | Wide Receiver | May play | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Bills | Jordan Hancock | Cornerback | Injury reserve | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Bills | Christian Benford | Cornerback | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Bills | Josh Allen | Quarterback | May play | Knee | Wed, Oct 7, 8:15 PM EDT |
| Bills | Joe Andreessen | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Bills | Damar Hamlin | Safety | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Bills | Deone Walker | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Bills | Sam Franklin Jr. | Safety | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Bills | Ray Davis | Running Back | May play | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Bills | Te'Cory Couch | Cornerback | May play | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Bills | Dee Alford | Cornerback | May play | Ankle | Wed, Oct 7, 8:15 PM EDT |
Consensus Bets on this game
No consensus data yet for Chargers at Bills. Check back closer to game time.
Previous games
Frequently asked questions
Who is favoured in Chargers vs Bills?
Buffalo Bills were favoured by 1.5 points (-1.5)
What is the spread for Chargers vs Bills?
Bills -1.5, Chargers +1.5. Opened at -0.5 for Bills
What time is Chargers vs Bills?
No game is currently scheduled
What is Chargers vs Bills head-to-head record?
Chargers 0, Bills 1 in recent games