NFL · Week 2
Lions vs Bills Betting Odds – Week 2
Last game: Thursday, September 17, 2026 · 8:15 PM EDT · Highmark Stadium, Buffalo, NY
Odds by Fanduel, updated Oct 9, 2:40 AM ET
Week 2
Thursday, September 17
8:15 PM EDT
@ Highmark Stadium, Buffalo, NY
Final: Lions 31, Bills 41
- Buffalo Bills are favored by 1.5 points at -176
- Expected total is 47.5 points, down from the opening 48
- Lions Offensive Tackle Giovanni Manu is Out 4+ games
Lions vs Bills odds
Odds by Fanduel, updated Oct 9, 2:40 AM ETBet at Fanduel
How has the line moved?
| Captured | Bills spread | Total |
|---|---|---|
| Fri, Sep 11, 8:15 PM EDT | -1.5 | 48 |
| Thu, Sep 17, 7:09 AM EDT | -1.5 | 48 |
| Tue, Sep 22, 6:03 PM EDT | -1.5 | 48 |
| Mon, Sep 28, 4:58 AM EDT | -1.5 | 48 |
| Sat, Oct 3, 3:52 PM EDT | -1.5 | 48 |
| Fri, Oct 9, 2:46 AM EDT | -1.5 | 47.5 |
Bills spread
Total (over/under)
Lions vs Bills team comparison
| Lions | Bills | |
|---|---|---|
| 2-2 | Record | 3-1 |
| 29.8 | Points per game | 31.8 |
| 31.8 | Opponent points/game | 26.8 |
| -2.0 | Points differential | +5.0 |
| 0 | Head-to-head wins | 1 |
Injuries on both sides
| Team | Player | Pos | Status | Injury | Updated |
|---|---|---|---|---|---|
 Lions | Giovanni Manu | Offensive Tackle | Out 4+ games | Knee | Wed, Oct 7, 8:15 PM EDT |
| Lions | Brian Branch | Safety | Out 4+ games | Achilles | Wed, Oct 7, 8:15 PM EDT |
| Lions | Kerby Joseph | Safety | Out 4+ games | Knee | Wed, Oct 7, 8:15 PM EDT |
| Lions | Kendrick Law | Wide Receiver | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Lions | Cade Mays | Center | Injury reserve | Wrist | Wed, Oct 7, 8:15 PM EDT |
| Lions | Isiah Pacheco | Running Back | Injury reserve | Back | Wed, Oct 7, 8:15 PM EDT |
| Lions | Payton Turner | Defensive End | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| Lions | Damone Clark | Linebacker | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Lions | Christian Izien | Safety | May play | out | Wed, Oct 7, 8:15 PM EDT |
| Lions | Ahmed Hassanein | Defensive End | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | Ennis Rakestraw Jr. | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | Jimmy Rolder | Linebacker | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | Mekhi Wingo | Defensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | Christian Mahogany | Guard | May play | Hip | Wed, Oct 7, 8:15 PM EDT |
| Lions | Blake Miller | Offensive Tackle | May play | Knee | Wed, Oct 7, 8:15 PM EDT |
| Lions | Juice Scruggs | Guard | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Lions | D.J. Reed | Cornerback | May play | Ribs | Wed, Oct 7, 8:15 PM EDT |
| Lions | Keith Abney II | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | Avonte Maddox | Cornerback | Injury reserve | Foot | Wed, Oct 7, 8:15 PM EDT |
| Lions | Ben Bartch | Guard | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Lions | Thomas Harper | Safety | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Lions | Tate Ratledge | Guard | May play | Elbow | Wed, Oct 7, 8:15 PM EDT |
| Lions | Tyler Conklin | Tight End | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | Bishop Fitzgerald | Safety | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | Devin White | Linebacker | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | DJ Wonnum | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Lions | Rock Ya-Sin | Cornerback | Likely out | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Lions | Tyleik Williams | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
 Bills | Tyrell Shavers | Wide Receiver | Out 4+ games | out | Wed, Oct 7, 8:15 PM EDT |
| Bills | Dorian Strong | Cornerback | Out 4+ games | nfi-r | Wed, Oct 7, 8:15 PM EDT |
| Bills | Ty Johnson | Running Back | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Bills | Phidarian Mathis | Defensive Tackle | Suspended | reserve-sus | Wed, Oct 7, 8:15 PM EDT |
| Bills | Zane Durant | Defensive Tackle | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| Bills | T.J. Sanders | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Bills | Skyler Bell | Wide Receiver | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Bills | Jude Bowry | Offensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Bills | Mike Danna | Defensive End | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Bills | Jalon Kilgore | Safety | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Bills | Ar'maj Reed-Adams | Guard | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Bills | Terrel Bernard | Linebacker | May play | Calf | Wed, Oct 7, 8:15 PM EDT |
| Bills | Cole Bishop | Safety | May play | Groin | Wed, Oct 7, 8:15 PM EDT |
| Bills | Ed Oliver | Defensive Tackle | May play | Knee | Wed, Oct 7, 8:15 PM EDT |
| Bills | DJ Moore | Wide Receiver | May play | Shoulder | Wed, Oct 7, 8:15 PM EDT |
| Bills | Keon Coleman | Wide Receiver | May play | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Bills | Jordan Hancock | Cornerback | Injury reserve | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Bills | Christian Benford | Cornerback | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Bills | Josh Allen | Quarterback | May play | Knee | Wed, Oct 7, 8:15 PM EDT |
| Bills | Joe Andreessen | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Bills | Damar Hamlin | Safety | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Bills | Deone Walker | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Bills | Sam Franklin Jr. | Safety | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Bills | Ray Davis | Running Back | May play | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Bills | Te'Cory Couch | Cornerback | May play | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Bills | Dee Alford | Cornerback | May play | Ankle | Wed, Oct 7, 8:15 PM EDT |
Consensus Bets on this game
No consensus data yet for Lions at Bills. Check back closer to game time.
Previous games
Frequently asked questions
Who is favoured in Lions vs Bills?
Buffalo Bills were favoured by 1.5 points (-1.5)
What is the spread for Lions vs Bills?
Bills -1.5, Lions +1.5. Opened at -1.5 for Bills
What time is Lions vs Bills?
No game is currently scheduled
What is Lions vs Bills head-to-head record?
Lions 0, Bills 1 in recent games