NFL · Week 2
Lions vs Bills Recap – Week 2
Last game: Thursday, September 17, 2026 · 8:00 PM EDT · Buffalo Arena, Buffalo, NY
Updated Oct 29, 8:35 AM ET
Week 2
Thursday, September 17
8:00 PM EDT
@ Buffalo Arena, Buffalo, NY
Final: Lions 31, Bills 41
- Buffalo Bills won 41–31 on Thursday, September 17
Lions vs Bills team comparison
| Lions | Bills | |
|---|---|---|
| 4-2 | Record | 5-1 |
| 30.7 | Points per game | 32.8 |
| 27.5 | Opponent points/game | 28.5 |
| +3.2 | Points differential | +4.3 |
| 0 | Head-to-head wins | 1 |
Injuries on both sides
| Team | Player | Pos | Status | Injury | Updated |
|---|---|---|---|---|---|
 Lions | Giovanni Manu | Offensive Tackle | Out 4+ games | Knee | Wed, Oct 7, 8:15 PM EDT |
| Lions | Brian Branch | Safety | Out 4+ games | Achilles | Wed, Oct 7, 8:15 PM EDT |
| Lions | Kerby Joseph | Safety | Out 4+ games | Knee | Wed, Oct 7, 8:15 PM EDT |
| Lions | Kendrick Law | Wide Receiver | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Lions | Cade Mays | Center | Injury reserve | Wrist | Wed, Oct 7, 8:15 PM EDT |
| Lions | Isiah Pacheco | Running Back | Injury reserve | Back | Wed, Oct 7, 8:15 PM EDT |
| Lions | Payton Turner | Defensive End | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| Lions | Damone Clark | Linebacker | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Lions | Christian Izien | Safety | May play | out | Wed, Oct 7, 8:15 PM EDT |
| Lions | Ahmed Hassanein | Defensive End | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | Ennis Rakestraw Jr. | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | Jimmy Rolder | Linebacker | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | Mekhi Wingo | Defensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | Christian Mahogany | Guard | May play | Hip | Wed, Oct 7, 8:15 PM EDT |
| Lions | Blake Miller | Offensive Tackle | May play | Knee | Wed, Oct 7, 8:15 PM EDT |
| Lions | Juice Scruggs | Guard | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Lions | D.J. Reed | Cornerback | May play | Ribs | Wed, Oct 7, 8:15 PM EDT |
| Lions | Keith Abney II | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | Avonte Maddox | Cornerback | Injury reserve | Foot | Wed, Oct 7, 8:15 PM EDT |
| Lions | Ben Bartch | Guard | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Lions | Thomas Harper | Safety | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Lions | Tate Ratledge | Guard | May play | Elbow | Wed, Oct 7, 8:15 PM EDT |
| Lions | Tyler Conklin | Tight End | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | Bishop Fitzgerald | Safety | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | Devin White | Linebacker | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | DJ Wonnum | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Lions | Rock Ya-Sin | Cornerback | Likely out | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Lions | Tyleik Williams | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
 Bills | Tyrell Shavers | Wide Receiver | Out 4+ games | out | Wed, Oct 7, 8:15 PM EDT |
| Bills | Dorian Strong | Cornerback | Out 4+ games | nfi-r | Wed, Oct 7, 8:15 PM EDT |
| Bills | Ty Johnson | Running Back | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Bills | Phidarian Mathis | Defensive Tackle | Suspended | reserve-sus | Wed, Oct 7, 8:15 PM EDT |
| Bills | Zane Durant | Defensive Tackle | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| Bills | T.J. Sanders | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Bills | Skyler Bell | Wide Receiver | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Bills | Jude Bowry | Offensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Bills | Mike Danna | Defensive End | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Bills | Jalon Kilgore | Safety | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Bills | Ar'maj Reed-Adams | Guard | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Bills | Terrel Bernard | Linebacker | May play | Calf | Wed, Oct 7, 8:15 PM EDT |
| Bills | Cole Bishop | Safety | May play | Groin | Wed, Oct 7, 8:15 PM EDT |
| Bills | Ed Oliver | Defensive Tackle | May play | Knee | Wed, Oct 7, 8:15 PM EDT |
| Bills | DJ Moore | Wide Receiver | May play | Shoulder | Wed, Oct 7, 8:15 PM EDT |
| Bills | Keon Coleman | Wide Receiver | May play | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Bills | Jordan Hancock | Cornerback | Injury reserve | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Bills | Christian Benford | Cornerback | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Bills | Josh Allen | Quarterback | May play | Knee | Wed, Oct 7, 8:15 PM EDT |
| Bills | Joe Andreessen | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Bills | Damar Hamlin | Safety | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Bills | Deone Walker | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Bills | Sam Franklin Jr. | Safety | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Bills | Ray Davis | Running Back | May play | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Bills | Te'Cory Couch | Cornerback | May play | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Bills | Dee Alford | Cornerback | May play | Ankle | Wed, Oct 7, 8:15 PM EDT |
Consensus Bets on this game
No consensus data yet for Lions at Bills. Check back closer to game time.
Previous games
Frequently asked questions
Who won Lions vs Bills?
Buffalo Bills won 41–31
What was the final score of Lions vs Bills?
Lions 31, Bills 41
When did Lions vs Bills play?
Thursday, September 17, 2026 at 8:00 PM EDT, Buffalo Arena, Buffalo, NY
What is Lions vs Bills head-to-head record?
Lions 0, Bills 1 in recent games