NFL · Week 5

Bills vs Rams Betting Odds – Week 5

Monday, October 12, 2026 · 8:15 PM EDT · SoFi Stadium, Los Angeles, CA

Odds by Fanduel, updated Oct 9, 1:31 AM ET

Bills Away3-1

Week 5

Monday, October 12

8:15 PM EDT

@ SoFi Stadium, Los Angeles, CA

Rams Home2-2

Buffalo Bills are favored by 4 points at -584, Monday, October 12 at 8:15 PM EDT
Expected total is 47.5 points, down from the opening 48.5
Bills Wide Receiver Tyrell Shavers is Out 4+ games

As of Oct 9, 1:31 AM ET

Bills vs Rams odds

Fanduel odds for Buffalo Bills at Los Angeles Rams
Market	Bills	Rams	Opened
Spread	-4 (-108)	+4 (-110)	-3.5 / +3.5
Total	O 47.5 (-110)	U 47.5 (-105)	O 48.5 / U 48.5
Moneyline	-584	+423	-578 / +417

Odds by Fanduel, updated Oct 9, 1:31 AM ETBet at Fanduel

How has the line moved?

Line movement since open
Captured	Rams spread	Total
Tue, Oct 6, 8:15 PM EDT	+3.5	48.5
Wed, Oct 7, 6:55 AM EDT	+3.5	48.5
Wed, Oct 7, 5:35 PM EDT	+3.5	48
Thu, Oct 8, 4:15 AM EDT	+3.5	48
Thu, Oct 8, 2:56 PM EDT	+4	48
Fri, Oct 9, 1:36 AM EDT	+4	47.5

Rams spread

Total (over/under)

Bills vs Rams team comparison

Team comparison
Bills		Rams
3-1	Record	2-2
31.8	Points per game	21.3
26.8	Opponent points/game	20.8
+5.0	Points differential	+0.5
0	Head-to-head wins	0

Injuries on both sides

Injury report
Team	Player	Pos	Status	Injury	Updated
Bills	Tyrell Shavers	Wide Receiver	Out 4+ games	out	Wed, Oct 7, 8:15 PM EDT
Bills	Dorian Strong	Cornerback	Out 4+ games	nfi-r	Wed, Oct 7, 8:15 PM EDT
Bills	Ty Johnson	Running Back	May play	questionable	Wed, Oct 7, 8:15 PM EDT
Bills	Phidarian Mathis	Defensive Tackle	Suspended	reserve-sus	Wed, Oct 7, 8:15 PM EDT
Bills	Zane Durant	Defensive Tackle	Injury reserve	ir	Wed, Oct 7, 8:15 PM EDT
Bills	T.J. Sanders	Defensive Tackle	May play	questionable	Wed, Oct 7, 8:15 PM EDT
Bills	Skyler Bell	Wide Receiver	Not playing	inactive	Wed, Oct 7, 8:15 PM EDT
Bills	Jude Bowry	Offensive Tackle	Not playing	inactive	Wed, Oct 7, 8:15 PM EDT
Bills	Mike Danna	Defensive End	Not playing	inactive	Wed, Oct 7, 8:15 PM EDT
Bills	Jalon Kilgore	Safety	Not playing	inactive	Wed, Oct 7, 8:15 PM EDT
Bills	Ar'maj Reed-Adams	Guard	Not playing	inactive	Wed, Oct 7, 8:15 PM EDT
Bills	Terrel Bernard	Linebacker	May play	Calf	Wed, Oct 7, 8:15 PM EDT
Bills	Cole Bishop	Safety	May play	Groin	Wed, Oct 7, 8:15 PM EDT
Bills	Ed Oliver	Defensive Tackle	May play	Knee	Wed, Oct 7, 8:15 PM EDT
Bills	DJ Moore	Wide Receiver	May play	Shoulder	Wed, Oct 7, 8:15 PM EDT
Bills	Keon Coleman	Wide Receiver	May play	Ankle	Wed, Oct 7, 8:15 PM EDT
Bills	Jordan Hancock	Cornerback	Injury reserve	Hamstring	Wed, Oct 7, 8:15 PM EDT
Bills	Christian Benford	Cornerback	May play	questionable	Wed, Oct 7, 8:15 PM EDT
Bills	Josh Allen	Quarterback	May play	Knee	Wed, Oct 7, 8:15 PM EDT
Bills	Joe Andreessen	Linebacker	May play	questionable	Wed, Oct 7, 8:15 PM EDT
Bills	Damar Hamlin	Safety	May play	questionable	Wed, Oct 7, 8:15 PM EDT
Bills	Deone Walker	Defensive Tackle	May play	questionable	Wed, Oct 7, 8:15 PM EDT
Bills	Sam Franklin Jr.	Safety	May play	questionable	Wed, Oct 7, 8:15 PM EDT
Bills	Ray Davis	Running Back	May play	Hamstring	Wed, Oct 7, 8:15 PM EDT
Bills	Te'Cory Couch	Cornerback	May play	Hamstring	Wed, Oct 7, 8:15 PM EDT
Bills	Dee Alford	Cornerback	May play	Ankle	Wed, Oct 7, 8:15 PM EDT
Rams	Justin Dedich	Guard	Injury reserve	Undisclosed	Wed, Oct 7, 8:15 PM EDT
Rams	Eddie Walls III	Linebacker	Injury reserve	Undisclosed	Wed, Oct 7, 8:15 PM EDT
Rams	Matthew Caldwell	Quarterback	Injury reserve	Undisclosed	Wed, Oct 7, 8:15 PM EDT
Rams	Daniel Rickert	Defensive End	Injury reserve	Knee	Wed, Oct 7, 8:15 PM EDT
Rams	Keir Thomas II	Linebacker	Injury reserve	ir	Wed, Oct 7, 8:15 PM EDT
Rams	Keagen Trost	Offensive Tackle	Injury reserve	Hamstring	Wed, Oct 7, 8:15 PM EDT
Rams	Tutu Atwell	Wide Receiver	Not playing	inactive	Wed, Oct 7, 8:15 PM EDT
Rams	CJ Daniels	Wide Receiver	Not playing	inactive	Wed, Oct 7, 8:15 PM EDT
Rams	Max Klare	Tight End	Not playing	Coach's decision	Wed, Oct 7, 8:15 PM EDT
Rams	Bill Murray	Guard	Not playing	inactive	Wed, Oct 7, 8:15 PM EDT
Rams	Ty Simpson	Quarterback	Not playing	Back	Wed, Oct 7, 8:15 PM EDT
Rams	Davis Allen	Tight End	May play	Concussion	Wed, Oct 7, 8:15 PM EDT
Rams	Kam Curl	Safety	May play	Ankle	Wed, Oct 7, 8:15 PM EDT
Rams	Myles Garrett	Defensive End	Injury reserve	Knee	Wed, Oct 7, 8:15 PM EDT
Rams	Nate Landman	Linebacker	May play	Shoulder	Wed, Oct 7, 8:15 PM EDT
Rams	Omar Speights	Linebacker	May play	Hip	Wed, Oct 7, 8:15 PM EDT
Rams	Kamren Kinchens	Safety	May play	Hamstring	Wed, Oct 7, 8:15 PM EDT
Rams	Puka Nacua	Wide Receiver	May play	Hip	Wed, Oct 7, 8:15 PM EDT
Rams	Jordan Whittington	Wide Receiver	May play	Quadriceps	Wed, Oct 7, 8:15 PM EDT
Rams	Ronnie Rivers	Running Back	Injury reserve	Calf	Wed, Oct 7, 8:15 PM EDT
Rams	Terrance Ferguson	Tight End	Injury reserve	Ankle	Wed, Oct 7, 8:15 PM EDT
Rams	Alaric Jackson	Offensive Tackle	May play	questionable	Wed, Oct 7, 8:15 PM EDT
Rams	Colby Parkinson	Tight End	May play	questionable	Wed, Oct 7, 8:15 PM EDT
Rams	Maximus Pulley	Safety	Not playing	inactive	Wed, Oct 7, 8:15 PM EDT
Rams	Jaylen Watson	Cornerback	May play	questionable	Wed, Oct 7, 8:15 PM EDT
Rams	Aaron Donald	Defensive Tackle	May play	questionable	Wed, Oct 7, 8:15 PM EDT
Rams	Josh Wallace	Cornerback	May play	questionable	Wed, Oct 7, 8:15 PM EDT
Rams	Josaiah Stewart	Linebacker	May play	questionable	Wed, Oct 7, 8:15 PM EDT
Rams	Cam Lampkin	Cornerback	Not playing	inactive	Wed, Oct 7, 8:15 PM EDT
Rams	Konata Mumpfield	Wide Receiver	May play	Rotator cuff	Wed, Oct 7, 8:15 PM EDT

Consensus Bets on this game

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Frequently asked questions

Who is favoured in Bills vs Rams on Monday, October 12?

Buffalo Bills are favoured by 4 points (-4)

What is the spread for Bills vs Rams on Monday, October 12?

Rams +4, Bills -4. Opened at +3.5 for Rams

What time is Bills vs Rams on Monday, October 12?

Monday, October 12, 2026 at 8:15 PM EDT, SoFi Stadium, Los Angeles, CA

What is Bills vs Rams head-to-head record?

Bills 0, Rams 0 in recent games