NFL · Week 16
49ers vs Chiefs Betting Odds – Week 16
Sunday, December 27, 2026 · 4:25 PM EST · Arrowhead Stadium, Kansas City, MO
Odds by Fanduel, updated Oct 9, 6:27 AM ET
Week 16
Sunday, December 27
4:25 PM EST
@ Arrowhead Stadium, Kansas City, MO
- San Francisco 49ers are favored by 1 points at -165, Sunday, December 27 at 4:25 PM EST
- Expected total is 48 points, down from the opening 49
- 49ers Fullback Kyle Juszczyk is Out
49ers vs Chiefs odds
Odds by Fanduel, updated Oct 9, 6:27 AM ETBet at Fanduel
How has the line moved?
| Captured | Chiefs spread | Total |
|---|---|---|
| Wed, Oct 7, 6:28 AM EDT | +1.5 | 49 |
| Wed, Oct 7, 4:04 PM EDT | +1.5 | 49 |
| Thu, Oct 8, 1:40 AM EDT | +1 | 48.5 |
| Thu, Oct 8, 11:16 AM EDT | +1 | 48 |
| Thu, Oct 8, 8:52 PM EDT | +1 | 48.5 |
| Fri, Oct 9, 6:28 AM EDT | +1 | 48 |
Chiefs spread
Total (over/under)
49ers vs Chiefs team comparison
| 49ers | Chiefs | |
|---|---|---|
| 4-0 | Record | 4-0 |
| 30.5 | Points per game | 29.5 |
| 16.0 | Opponent points/game | 19.3 |
| +14.5 | Points differential | +10.3 |
| 0 | Head-to-head wins | 0 |
Injuries on both sides
| Team | Player | Pos | Status | Injury | Updated |
|---|---|---|---|---|---|
 49ers | Isaac Guerendo | Running Back | Out 4+ games | Pectoral | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Brandon Aiyuk | Wide Receiver | Reserve | Head | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Christian Kirk | Wide Receiver | Injury reserve | Calf | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Mykel Williams | Defensive End | Out 4+ games | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Ricky Pearsall | Wide Receiver | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Andrew Farmer II | Defensive End | Injury reserve | Back | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Darrick Forrest | Safety | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Mikail Kamara | Defensive End | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Sam Okuayinonu | Defensive Tackle | Injury reserve | Foot | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Brett Toth | Center | Injury reserve | Concussion | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Nate Hobbs | Cornerback | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Nick Martin | Linebacker | Injury reserve | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Austen Pleasants | Offensive Tackle | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Nick Zakelj | Offensive Tackle | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Alfred Collins | Defensive Tackle | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Tatum Bethune | Linebacker | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Enrique Cruz Jr. | Offensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jordan James | Running Back | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Ephesians Prysock | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Kurtis Rourke | Quarterback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jordan Watkins | Wide Receiver | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| 49ers | De'Zhaun Stribling | Wide Receiver | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jake Tonges | Tight End | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Kyle Juszczyk | Fullback | Out | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Khalid Kareem | Defensive End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| 49ers | George Kittle | Tight End | May play | Achilles | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Eddy Pineiro | Place Kicker | May play | Illness | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Keion White | Defensive End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Kaelon Black | Running Back | May play | Illness | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Romello Height | Defensive End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jack Jones | Cornerback | May play | Foot | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Demarcus Robinson | Wide Receiver | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Mike Evans | Wide Receiver | May play | Ribs | Wed, Oct 7, 8:15 PM EDT |
| 49ers | James Thompson Jr. | Defensive Tackle | Likely out | doubtful | Wed, Oct 7, 8:15 PM EDT |
| 49ers | C.J. West | Defensive Tackle | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Nick Bosa | Defensive End | Likely out | doubtful | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Dre Greenlaw | Linebacker | May play | Quadriceps | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Gracen Halton | Defensive Tackle | May play | Ankle | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Trent Williams | Offensive Tackle | May play | Neck | Wed, Oct 7, 8:15 PM EDT |
| 49ers | KhaDarel Hodge | Wide Receiver | May play | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jaden Dugger | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Marques Sigle | Safety | Out | out | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Upton Stout | Cornerback | May play | Shoulder | Wed, Oct 7, 8:15 PM EDT |
 Chiefs | Omarr Norman-Lott | Defensive Tackle | Out 4+ games | Knee | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Ethan Downs | Linebacker | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | John Michael Gyllenborg | Tight End | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Jeff Caldwell | Wide Receiver | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Jimmy Holiday | Wide Receiver | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Josh Simmons | Offensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Matt Waletzko | Offensive Tackle | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Chamarri Conner | Safety | May play | Knee | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Bryson Eason | Defensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Garrett Nussmeier | Quarterback | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Diego Pounds | Offensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Jack Pyburn | Linebacker | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Jared Wiley | Tight End | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Mansoor Delane | Cornerback | May play | Shoulder | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Cooper McDonald | Linebacker | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Chris Jones | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Felix Anudike-Uzomah | Defensive End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | L'Jarius Sneed | Cornerback | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Tyreke Smith | Defensive End | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Jadon Canady | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Rashee Rice | Wide Receiver | May play | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Tyquan Thornton | Wide Receiver | Out | Ankle | Wed, Oct 7, 8:15 PM EDT |
Consensus Bets on this game
No consensus data yet for 49ers at Chiefs. Check back closer to game time.
Frequently asked questions
Who is favoured in 49ers vs Chiefs on Sunday, December 27?
San Francisco 49ers are favoured by 1 points (-1)
What is the spread for 49ers vs Chiefs on Sunday, December 27?
Chiefs +1, 49ers -1. Opened at +1.5 for Chiefs
What time is 49ers vs Chiefs on Sunday, December 27?
Sunday, December 27, 2026 at 4:25 PM EST, Arrowhead Stadium, Kansas City, MO
What is 49ers vs Chiefs head-to-head record?
49ers 0, Chiefs 0 in recent games