NFL · Week 4
Broncos vs 49ers Betting Odds – Week 4
Last game: Sunday, October 4, 2026 · 4:25 PM EDT · Levi's Stadium, San Francisco, CA
Odds by Fanduel, updated Oct 9, 6:21 AM ET
Week 4
Sunday, October 4
4:25 PM EDT
@ Levi's Stadium, San Francisco, CA
Final: Broncos 14, 49ers 24
- Denver Broncos are favored by 1 points at -163
- Expected total is 43 points, up from the opening 41.5
- 49ers Fullback Kyle Juszczyk is Out
Broncos vs 49ers odds
Odds by Fanduel, updated Oct 9, 6:21 AM ETBet at Fanduel
How has the line moved?
| Captured | 49ers spread | Total |
|---|---|---|
| Mon, Sep 28, 4:25 PM EDT | +2.5 | 41.5 |
| Wed, Sep 30, 7:13 PM EDT | +2.5 | 42 |
| Fri, Oct 2, 10:02 PM EDT | +1.5 | 42 |
| Mon, Oct 5, 12:51 AM EDT | +1.5 | 42.5 |
| Wed, Oct 7, 3:40 AM EDT | +1.5 | 42.5 |
| Fri, Oct 9, 6:29 AM EDT | +1 | 43 |
49ers spread
Total (over/under)
Broncos vs 49ers team comparison
| Broncos | 49ers | |
|---|---|---|
| 2-2 | Record | 4-0 |
| 18.5 | Points per game | 30.5 |
| 23.5 | Opponent points/game | 16.0 |
| -5.0 | Points differential | +14.5 |
| 0 | Head-to-head wins | 1 |
Injuries on both sides
| Team | Player | Pos | Status | Injury | Updated |
|---|---|---|---|---|---|
 Broncos | Caleb Lohner | Tight End | Injury reserve | Lower body | Wed, Oct 7, 8:15 PM EDT |
| Broncos | Nick Gargiulo | Guard | Out 4+ games | Knee | Wed, Oct 7, 8:15 PM EDT |
| Broncos | Michael Deiter | Center | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| Broncos | Matt Henningsen | Defensive End | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| Broncos | Levelle Bailey | Linebacker | Injury reserve | Leg | Wed, Oct 7, 8:15 PM EDT |
| Broncos | Frank Crum | Offensive Tackle | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Broncos | Tyler Badie | Running Back | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| Broncos | Dallen Bentley | Tight End | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| Broncos | Kage Casey | Offensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Broncos | Sam Ehlinger | Quarterback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Broncos | Jordan Jackson | Defensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Broncos | Tyler Onyedim | Defensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Broncos | Marvin Mims Jr. | Wide Receiver | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Broncos | RJ Harvey | Running Back | May play | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Broncos | J.K. Dobbins | Running Back | May play | Hip | Wed, Oct 7, 8:15 PM EDT |
| Broncos | Jonah Coleman | Running Back | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Broncos | Lil'Jordan Humphrey | Wide Receiver | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Broncos | Sai'vion Jones | Defensive End | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Broncos | Jaylen Waddle | Wide Receiver | May play | Foot | Wed, Oct 7, 8:15 PM EDT |
| Broncos | Dondrea Tillman | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Broncos | Pat Bryant | Wide Receiver | Likely out | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Broncos | Riley Moss | Cornerback | May play | Rib | Wed, Oct 7, 8:15 PM EDT |
| Broncos | Adam Trautman | Tight End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
 49ers | Isaac Guerendo | Running Back | Out 4+ games | Pectoral | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Brandon Aiyuk | Wide Receiver | Reserve | Head | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Christian Kirk | Wide Receiver | Injury reserve | Calf | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Mykel Williams | Defensive End | Out 4+ games | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Ricky Pearsall | Wide Receiver | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Andrew Farmer II | Defensive End | Injury reserve | Back | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Darrick Forrest | Safety | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Mikail Kamara | Defensive End | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Sam Okuayinonu | Defensive Tackle | Injury reserve | Foot | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Brett Toth | Center | Injury reserve | Concussion | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Nate Hobbs | Cornerback | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Nick Martin | Linebacker | Injury reserve | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Austen Pleasants | Offensive Tackle | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Nick Zakelj | Offensive Tackle | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Alfred Collins | Defensive Tackle | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Tatum Bethune | Linebacker | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Enrique Cruz Jr. | Offensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jordan James | Running Back | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Ephesians Prysock | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Kurtis Rourke | Quarterback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jordan Watkins | Wide Receiver | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| 49ers | De'Zhaun Stribling | Wide Receiver | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jake Tonges | Tight End | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Kyle Juszczyk | Fullback | Out | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Khalid Kareem | Defensive End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| 49ers | George Kittle | Tight End | May play | Achilles | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Eddy Pineiro | Place Kicker | May play | Illness | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Keion White | Defensive End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Kaelon Black | Running Back | May play | Illness | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Romello Height | Defensive End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jack Jones | Cornerback | May play | Foot | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Demarcus Robinson | Wide Receiver | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Mike Evans | Wide Receiver | May play | Ribs | Wed, Oct 7, 8:15 PM EDT |
| 49ers | James Thompson Jr. | Defensive Tackle | Likely out | doubtful | Wed, Oct 7, 8:15 PM EDT |
| 49ers | C.J. West | Defensive Tackle | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Nick Bosa | Defensive End | Likely out | doubtful | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Dre Greenlaw | Linebacker | May play | Quadriceps | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Gracen Halton | Defensive Tackle | May play | Ankle | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Trent Williams | Offensive Tackle | May play | Neck | Wed, Oct 7, 8:15 PM EDT |
| 49ers | KhaDarel Hodge | Wide Receiver | May play | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jaden Dugger | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Marques Sigle | Safety | Out | out | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Upton Stout | Cornerback | May play | Shoulder | Wed, Oct 7, 8:15 PM EDT |
Consensus Bets on this game
No consensus data yet for Broncos at 49ers. Check back closer to game time.
Previous games
Frequently asked questions
Who is favoured in Broncos vs 49ers?
Denver Broncos were favoured by 1 points (-1)
What is the spread for Broncos vs 49ers?
49ers +1, Broncos -1. Opened at +2.5 for 49ers
What time is Broncos vs 49ers?
No game is currently scheduled
What is Broncos vs 49ers head-to-head record?
Broncos 0, 49ers 1 in recent games