NFL · Week 10
49ers vs Cowboys Betting Odds – Week 10
Sunday, November 15, 2026 · 4:25 PM EST · AT&T Stadium, Dallas, TX
Odds by Fanduel, updated Oct 9, 3:30 AM ET
- Dallas Cowboys are favored by 1 points at -167, Sunday, November 15 at 4:25 PM EST
- Expected total is 45 points, down from the opening 45.5
- 49ers Fullback Kyle Juszczyk is Out
49ers vs Cowboys odds
Odds by Fanduel, updated Oct 9, 3:30 AM ETBet at Fanduel
How has the line moved?
| Captured | Cowboys spread | Total |
|---|---|---|
| Wed, Oct 7, 3:38 AM EDT | -2 | 45.5 |
| Wed, Oct 7, 1:14 PM EDT | -2 | 45 |
| Wed, Oct 7, 10:50 PM EDT | -1.5 | 45 |
| Thu, Oct 8, 8:26 AM EDT | -1.5 | 45 |
| Thu, Oct 8, 6:02 PM EDT | -1 | 45 |
| Fri, Oct 9, 3:38 AM EDT | -1 | 45 |
Cowboys spread
Total (over/under)
49ers vs Cowboys team comparison
| 49ers | Cowboys | |
|---|---|---|
| 4-0 | Record | 2-2 |
| 30.5 | Points per game | 30.5 |
| 16.0 | Opponent points/game | 28.0 |
| +14.5 | Points differential | +2.5 |
| 0 | Head-to-head wins | 0 |
Injuries on both sides
| Team | Player | Pos | Status | Injury | Updated |
|---|---|---|---|---|---|
 49ers | Isaac Guerendo | Running Back | Out 4+ games | Pectoral | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Brandon Aiyuk | Wide Receiver | Reserve | Head | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Christian Kirk | Wide Receiver | Injury reserve | Calf | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Mykel Williams | Defensive End | Out 4+ games | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Ricky Pearsall | Wide Receiver | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Andrew Farmer II | Defensive End | Injury reserve | Back | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Darrick Forrest | Safety | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Mikail Kamara | Defensive End | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Sam Okuayinonu | Defensive Tackle | Injury reserve | Foot | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Brett Toth | Center | Injury reserve | Concussion | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Nate Hobbs | Cornerback | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Nick Martin | Linebacker | Injury reserve | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Austen Pleasants | Offensive Tackle | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Nick Zakelj | Offensive Tackle | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Alfred Collins | Defensive Tackle | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Tatum Bethune | Linebacker | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Enrique Cruz Jr. | Offensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jordan James | Running Back | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Ephesians Prysock | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Kurtis Rourke | Quarterback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jordan Watkins | Wide Receiver | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| 49ers | De'Zhaun Stribling | Wide Receiver | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jake Tonges | Tight End | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Kyle Juszczyk | Fullback | Out | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Khalid Kareem | Defensive End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| 49ers | George Kittle | Tight End | May play | Achilles | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Eddy Pineiro | Place Kicker | May play | Illness | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Keion White | Defensive End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Kaelon Black | Running Back | May play | Illness | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Romello Height | Defensive End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jack Jones | Cornerback | May play | Foot | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Demarcus Robinson | Wide Receiver | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Mike Evans | Wide Receiver | May play | Ribs | Wed, Oct 7, 8:15 PM EDT |
| 49ers | James Thompson Jr. | Defensive Tackle | Likely out | doubtful | Wed, Oct 7, 8:15 PM EDT |
| 49ers | C.J. West | Defensive Tackle | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Nick Bosa | Defensive End | Likely out | doubtful | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Dre Greenlaw | Linebacker | May play | Quadriceps | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Gracen Halton | Defensive Tackle | May play | Ankle | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Trent Williams | Offensive Tackle | May play | Neck | Wed, Oct 7, 8:15 PM EDT |
| 49ers | KhaDarel Hodge | Wide Receiver | May play | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jaden Dugger | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Marques Sigle | Safety | Out | out | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Upton Stout | Cornerback | May play | Shoulder | Wed, Oct 7, 8:15 PM EDT |
 Cowboys | Princeton Fant | Tight End | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| Cowboys | Matt Hennessy | Center | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| Cowboys | Kelvin Gilliam Jr. | Defensive Tackle | Injury reserve | Triceps | Wed, Oct 7, 8:15 PM EDT |
| Cowboys | Marist Liufau | Linebacker | Injury reserve | Forearm | Wed, Oct 7, 8:15 PM EDT |
| Cowboys | Devin Moore | Cornerback | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| Cowboys | DJ Rogers | Tight End | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Cowboys | Tyler Smith | Guard | Injury reserve | Thumb | Wed, Oct 7, 8:15 PM EDT |
| Cowboys | Joey Porter Jr. | Cornerback | May play | Back | Wed, Oct 7, 8:15 PM EDT |
| Cowboys | Malik Davis | Running Back | Injury reserve | Hip | Wed, Oct 7, 8:15 PM EDT |
| Cowboys | Israel Abanikanda | Running Back | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Cowboys | Camden Brown | Wide Receiver | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| Cowboys | Caelen Carson | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Cowboys | Ajani Cornelius | Offensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Cowboys | Tyrus Wheat | Linebacker | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Cowboys | DeMarvion Overshown | Linebacker | Out | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Cowboys | Malik Hooker | Safety | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Cowboys | James Houston | Linebacker | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Cowboys | Tyler Goodson | Running Back | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| Cowboys | P.J. Locke | Safety | Injury reserve | Foot | Wed, Oct 7, 8:15 PM EDT |
| Cowboys | Cobie Durant | Cornerback | Out | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Cowboys | Emari Demercado | Running Back | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| Cowboys | Jalen Thompson | Safety | Injury reserve | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Cowboys | Jonathan Bullard | Defensive Tackle | Injury reserve | Calf | Wed, Oct 7, 8:15 PM EDT |
| Cowboys | Shavon Revel Jr. | Cornerback | May play | Knee/ankle | Wed, Oct 7, 8:15 PM EDT |
| Cowboys | Drew Shelton | Offensive Tackle | Out | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Cowboys | Jonathan Mingo | Wide Receiver | May play | Illness | Wed, Oct 7, 8:15 PM EDT |
Consensus Bets on this game
No consensus data yet for 49ers at Cowboys. Check back closer to game time.
Frequently asked questions
Who is favoured in 49ers vs Cowboys on Sunday, November 15?
Dallas Cowboys are favoured by 1 points (-1)
What is the spread for 49ers vs Cowboys on Sunday, November 15?
Cowboys -1, 49ers +1. Opened at -2 for Cowboys
What time is 49ers vs Cowboys on Sunday, November 15?
Sunday, November 15, 2026 at 4:25 PM EST, AT&T Stadium, Dallas, TX
What is 49ers vs Cowboys head-to-head record?
49ers 0, Cowboys 0 in recent games