NFL · Week 1
Cardinals vs Chargers Betting Odds – Week 1
Last game: Sunday, September 13, 2026 · 4:25 PM EDT · SoFi Stadium, Los Angeles, CA
Odds by Fanduel, updated Oct 9, 3:37 AM ET
Week 1
Sunday, September 13
4:25 PM EDT
@ SoFi Stadium, Los Angeles, CA
Final: Cardinals 26, Chargers 14
- Los Angeles Chargers are favored by 3 points at -380
- Expected total is 46 points, up from the opening 45.5
- Chargers Offensive Tackle Rashawn Slater is Out
Cardinals vs Chargers odds
Odds by Fanduel, updated Oct 9, 3:37 AM ETBet at Fanduel
How has the line moved?
| Captured | Chargers spread | Total |
|---|---|---|
| Mon, Sep 7, 4:25 PM EDT | -1.5 | 45.5 |
| Sun, Sep 13, 11:27 PM EDT | -1.5 | 45.5 |
| Sun, Sep 20, 6:30 AM EDT | -2 | 46 |
| Sat, Sep 26, 1:33 PM EDT | -2.5 | 45.5 |
| Fri, Oct 2, 8:36 PM EDT | -2.5 | 46 |
| Fri, Oct 9, 3:39 AM EDT | -3 | 46 |
Chargers spread
Total (over/under)
Cardinals vs Chargers team comparison
| Cardinals | Chargers | |
|---|---|---|
| 1-3 | Record | 0-4 |
| 21.8 | Points per game | 16.8 |
| 29.3 | Opponent points/game | 26.5 |
| -7.5 | Points differential | -9.8 |
| 1 | Head-to-head wins | 0 |
Injuries on both sides
| Team | Player | Pos | Status | Injury | Updated |
|---|---|---|---|---|---|
 Cardinals | James Conner | Running Back | Injury reserve | Foot | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Tip Reiman | Tight End | Out 4+ games | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Joey Blount | Safety | Injury reserve | Neck | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Zachary Carter | Defensive Tackle | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Kaleb Proctor | Defensive Tackle | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Chase Bisontis | Guard | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Trey Benson | Running Back | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Jameson Geers | Tight End | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Dadrion Taylor-Demerson | Safety | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Isaiah Adams | Guard | May play | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Garrett Williams | Cornerback | May play | Achilles | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Carson Beck | Quarterback | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Andrew Billings | Defensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Reggie Virgil | Wide Receiver | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Kitan Crawford | Safety | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Jack Gibbens | Linebacker | May play | Shoulder | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Roy Lopez | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Max Melton | Cornerback | May play | Toe | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Isaac Seumalo | Guard | May play | Shoulder | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Cody Simon | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Josh Fryar | Offensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Will Johnson | Cornerback | Injury reserve | Neck | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Hjalte Froholdt | Center | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Walter Nolen III | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Mack Wilson Sr. | Linebacker | May play | Thumb | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Josh Sweat | Linebacker | May play | Groin | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Cameron Robertson | Linebacker | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Starling Thomas V | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Andrew Wingard | Safety | May play | Knee | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Hunter Long | Tight End | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Paris Johnson Jr. | Offensive Tackle | Injury reserve | Biceps | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Jeremiyah Love | Running Back | May play | Ankle | Wed, Oct 7, 8:15 PM EDT |
 Chargers | Isaiah World | Offensive Tackle | Out 4+ games | nfi-r | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Tyler Biadasz | Center | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Scott Matlock | Fullback | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Denzel Perryman | Linebacker | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Branson Taylor | Guard | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Deane Leonard | Cornerback | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Alex Harkey | Guard | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Chargers | RJ Mickens | Safety | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Trevor Penning | Guard | May play | Head | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Logan Taylor | Guard | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Ladd McConkey | Wide Receiver | May play | Foot | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Elijah Molden | Cornerback | May play | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Chargers | KeAndre Lambert-Smith | Wide Receiver | Injury reserve | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Derius Davis | Wide Receiver | May play | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Trey Pipkins III | Offensive Tackle | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Teair Tart | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Dalvin Tomlinson | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Isas Waxter | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Derwin James Jr. | Safety | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | David Njoku | Tight End | Injury reserve | Fibula | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Kayode Awosika | Guard | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Charlie Kolar | Tight End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Brenen Thompson | Wide Receiver | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Rodney Shelley | Cornerback | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Rashawn Slater | Offensive Tackle | Out | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Cole Strange | Guard | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Tuli Tuipulotu | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Trey Lance | Quarterback | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | DJ Uiagalelei | Quarterback | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Donte Jackson | Cornerback | May play | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Justin Eboigbe | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Keaton Mitchell | Running Back | May play | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Joe Alt | Offensive Tackle | May play | Neck | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Quentin Johnston | Wide Receiver | May play | Johnston was limited at Wednes… | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Cam Hart | Cornerback | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Alec Ingold | Fullback | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
Consensus Bets on this game
No consensus data yet for Cardinals at Chargers. Check back closer to game time.
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Frequently asked questions
Who is favoured in Cardinals vs Chargers?
Los Angeles Chargers were favoured by 3 points (-3)
What is the spread for Cardinals vs Chargers?
Chargers -3, Cardinals +3. Opened at -1.5 for Chargers
What time is Cardinals vs Chargers?
No game is currently scheduled
What is Cardinals vs Chargers head-to-head record?
Cardinals 1, Chargers 0 in recent games