NFL · Week 5
Lions vs Cardinals Recap – Week 5
Last game: Saturday, October 10, 2026 · 8:00 PM EDT · Arizona Arena, Arizona, AZ
Updated Oct 29, 8:39 AM ET
Week 5
Saturday, October 10
8:00 PM EDT
@ Arizona Arena, Arizona, AZ
Final: Lions 45, Cardinals 21
- Detroit Lions won 45–21 on Saturday, October 10
Lions vs Cardinals closing odds
Odds by Fanduel, updated Oct 8, 2:00 PM ETBet at Fanduel
How did the line move?
| Captured | Cardinals spread | Total |
|---|---|---|
| Thu, Oct 8, 2:00 PM EDT | -5.5 | 54.5 |
Cardinals spread
Total (over/under)
Lions vs Cardinals team comparison
| Lions | Cardinals | |
|---|---|---|
| 4-2 | Record | 2-5 |
| 30.7 | Points per game | 20.3 |
| 27.5 | Opponent points/game | 29.7 |
| +3.2 | Points differential | -9.4 |
| 1 | Head-to-head wins | 0 |
Injuries on both sides
| Team | Player | Pos | Status | Injury | Updated |
|---|---|---|---|---|---|
 Lions | Giovanni Manu | Offensive Tackle | Out 4+ games | Knee | Wed, Oct 7, 8:15 PM EDT |
| Lions | Brian Branch | Safety | Out 4+ games | Achilles | Wed, Oct 7, 8:15 PM EDT |
| Lions | Kerby Joseph | Safety | Out 4+ games | Knee | Wed, Oct 7, 8:15 PM EDT |
| Lions | Kendrick Law | Wide Receiver | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Lions | Cade Mays | Center | Injury reserve | Wrist | Wed, Oct 7, 8:15 PM EDT |
| Lions | Isiah Pacheco | Running Back | Injury reserve | Back | Wed, Oct 7, 8:15 PM EDT |
| Lions | Payton Turner | Defensive End | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| Lions | Damone Clark | Linebacker | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Lions | Christian Izien | Safety | May play | out | Wed, Oct 7, 8:15 PM EDT |
| Lions | Ahmed Hassanein | Defensive End | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | Ennis Rakestraw Jr. | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | Jimmy Rolder | Linebacker | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | Mekhi Wingo | Defensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | Christian Mahogany | Guard | May play | Hip | Wed, Oct 7, 8:15 PM EDT |
| Lions | Blake Miller | Offensive Tackle | May play | Knee | Wed, Oct 7, 8:15 PM EDT |
| Lions | Juice Scruggs | Guard | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Lions | D.J. Reed | Cornerback | May play | Ribs | Wed, Oct 7, 8:15 PM EDT |
| Lions | Keith Abney II | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | Avonte Maddox | Cornerback | Injury reserve | Foot | Wed, Oct 7, 8:15 PM EDT |
| Lions | Ben Bartch | Guard | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Lions | Thomas Harper | Safety | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Lions | Tate Ratledge | Guard | May play | Elbow | Wed, Oct 7, 8:15 PM EDT |
| Lions | Tyler Conklin | Tight End | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | Bishop Fitzgerald | Safety | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | Devin White | Linebacker | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | DJ Wonnum | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Lions | Rock Ya-Sin | Cornerback | Likely out | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Lions | Tyleik Williams | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
 Cardinals | James Conner | Running Back | Injury reserve | Foot | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Tip Reiman | Tight End | Out 4+ games | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Joey Blount | Safety | Injury reserve | Neck | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Zachary Carter | Defensive Tackle | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Kaleb Proctor | Defensive Tackle | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Chase Bisontis | Guard | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Trey Benson | Running Back | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Jameson Geers | Tight End | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Dadrion Taylor-Demerson | Safety | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Isaiah Adams | Guard | May play | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Garrett Williams | Cornerback | May play | Achilles | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Carson Beck | Quarterback | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Andrew Billings | Defensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Reggie Virgil | Wide Receiver | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Kitan Crawford | Safety | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Jack Gibbens | Linebacker | May play | Shoulder | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Roy Lopez | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Max Melton | Cornerback | May play | Toe | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Isaac Seumalo | Guard | May play | Shoulder | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Cody Simon | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Josh Fryar | Offensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Will Johnson | Cornerback | Injury reserve | Neck | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Hjalte Froholdt | Center | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Walter Nolen III | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Mack Wilson Sr. | Linebacker | May play | Thumb | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Josh Sweat | Linebacker | May play | Groin | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Cameron Robertson | Linebacker | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Starling Thomas V | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Andrew Wingard | Safety | May play | Knee | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Hunter Long | Tight End | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Paris Johnson Jr. | Offensive Tackle | Injury reserve | Biceps | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Jeremiyah Love | Running Back | May play | Ankle | Wed, Oct 7, 8:15 PM EDT |
Consensus Bets on this game
No consensus data yet for Lions at Cardinals. Check back closer to game time.
Previous games
Frequently asked questions
Who won Lions vs Cardinals?
Detroit Lions won 45–21
What was the final score of Lions vs Cardinals?
Lions 45, Cardinals 21
When did Lions vs Cardinals play?
Saturday, October 10, 2026 at 8:00 PM EDT, Arizona Arena, Arizona, AZ
What is Lions vs Cardinals head-to-head record?
Lions 1, Cardinals 0 in recent games