NFL · Week 5
Lions vs Cardinals Betting Odds – Week 5
Sunday, October 11, 2026 · 4:25 PM EDT · State Farm Stadium, Arizona, AZ
Odds by Fanduel, updated Oct 9, 2:30 AM ET
- Detroit Lions are favored by 2 points at -248, Sunday, October 11 at 4:25 PM EDT
- Expected total is 47 points, down from the opening 47.5
- Lions Offensive Tackle Giovanni Manu is Out 4+ games
Lions vs Cardinals odds
Odds by Fanduel, updated Oct 9, 2:30 AM ETBet at Fanduel
How has the line moved?
| Captured | Cardinals spread | Total |
|---|---|---|
| Mon, Oct 5, 4:25 PM EDT | +1 | 47.5 |
| Tue, Oct 6, 8:51 AM EDT | +1 | 47.5 |
| Wed, Oct 7, 1:17 AM EDT | +1.5 | 47.5 |
| Wed, Oct 7, 5:43 PM EDT | +1.5 | 47.5 |
| Thu, Oct 8, 10:09 AM EDT | +2 | 47.5 |
| Fri, Oct 9, 2:35 AM EDT | +2 | 47 |
Cardinals spread
Total (over/under)
Lions vs Cardinals team comparison
| Lions | Cardinals | |
|---|---|---|
| 2-2 | Record | 1-3 |
| 29.8 | Points per game | 21.8 |
| 31.8 | Opponent points/game | 29.3 |
| -2.0 | Points differential | -7.5 |
| 0 | Head-to-head wins | 0 |
Injuries on both sides
| Team | Player | Pos | Status | Injury | Updated |
|---|---|---|---|---|---|
 Lions | Giovanni Manu | Offensive Tackle | Out 4+ games | Knee | Wed, Oct 7, 8:15 PM EDT |
| Lions | Brian Branch | Safety | Out 4+ games | Achilles | Wed, Oct 7, 8:15 PM EDT |
| Lions | Kerby Joseph | Safety | Out 4+ games | Knee | Wed, Oct 7, 8:15 PM EDT |
| Lions | Kendrick Law | Wide Receiver | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Lions | Cade Mays | Center | Injury reserve | Wrist | Wed, Oct 7, 8:15 PM EDT |
| Lions | Isiah Pacheco | Running Back | Injury reserve | Back | Wed, Oct 7, 8:15 PM EDT |
| Lions | Payton Turner | Defensive End | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| Lions | Damone Clark | Linebacker | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Lions | Christian Izien | Safety | May play | out | Wed, Oct 7, 8:15 PM EDT |
| Lions | Ahmed Hassanein | Defensive End | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | Ennis Rakestraw Jr. | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | Jimmy Rolder | Linebacker | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | Mekhi Wingo | Defensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | Christian Mahogany | Guard | May play | Hip | Wed, Oct 7, 8:15 PM EDT |
| Lions | Blake Miller | Offensive Tackle | May play | Knee | Wed, Oct 7, 8:15 PM EDT |
| Lions | Juice Scruggs | Guard | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Lions | D.J. Reed | Cornerback | May play | Ribs | Wed, Oct 7, 8:15 PM EDT |
| Lions | Keith Abney II | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | Avonte Maddox | Cornerback | Injury reserve | Foot | Wed, Oct 7, 8:15 PM EDT |
| Lions | Ben Bartch | Guard | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Lions | Thomas Harper | Safety | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Lions | Tate Ratledge | Guard | May play | Elbow | Wed, Oct 7, 8:15 PM EDT |
| Lions | Tyler Conklin | Tight End | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | Bishop Fitzgerald | Safety | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | Devin White | Linebacker | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | DJ Wonnum | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Lions | Rock Ya-Sin | Cornerback | Likely out | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Lions | Tyleik Williams | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
 Cardinals | James Conner | Running Back | Injury reserve | Foot | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Tip Reiman | Tight End | Out 4+ games | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Joey Blount | Safety | Injury reserve | Neck | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Zachary Carter | Defensive Tackle | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Kaleb Proctor | Defensive Tackle | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Chase Bisontis | Guard | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Trey Benson | Running Back | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Jameson Geers | Tight End | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Dadrion Taylor-Demerson | Safety | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Isaiah Adams | Guard | May play | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Garrett Williams | Cornerback | May play | Achilles | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Carson Beck | Quarterback | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Andrew Billings | Defensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Reggie Virgil | Wide Receiver | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Kitan Crawford | Safety | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Jack Gibbens | Linebacker | May play | Shoulder | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Roy Lopez | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Max Melton | Cornerback | May play | Toe | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Isaac Seumalo | Guard | May play | Shoulder | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Cody Simon | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Josh Fryar | Offensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Will Johnson | Cornerback | Injury reserve | Neck | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Hjalte Froholdt | Center | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Walter Nolen III | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Mack Wilson Sr. | Linebacker | May play | Thumb | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Josh Sweat | Linebacker | May play | Groin | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Cameron Robertson | Linebacker | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Starling Thomas V | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Andrew Wingard | Safety | May play | Knee | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Hunter Long | Tight End | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Paris Johnson Jr. | Offensive Tackle | Injury reserve | Biceps | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Jeremiyah Love | Running Back | May play | Ankle | Wed, Oct 7, 8:15 PM EDT |
Consensus Bets on this game
Premium members only
Sign in or become a member to see today's picks and consensus bets.
Frequently asked questions
Who is favoured in Lions vs Cardinals on Sunday, October 11?
Detroit Lions are favoured by 2 points (-2)
What is the spread for Lions vs Cardinals on Sunday, October 11?
Cardinals +2, Lions -2. Opened at +1 for Cardinals
What time is Lions vs Cardinals on Sunday, October 11?
Sunday, October 11, 2026 at 4:25 PM EDT, State Farm Stadium, Arizona, AZ
What is Lions vs Cardinals head-to-head record?
Lions 0, Cardinals 0 in recent games