NFL · Week 16
Cardinals vs Saints Betting Odds – Week 16
Sunday, December 27, 2026 · 1:00 PM EST · Caesars Superdome, New Orleans, LA
Odds by Fanduel, updated Oct 9, 1:42 AM ET
Week 16
Sunday, December 27
1:00 PM EST
@ Caesars Superdome, New Orleans, LA
- Arizona Cardinals are favored by 1.5 points at -184, Sunday, December 27 at 1:00 PM EST
- Expected total is 47.5 points, up from the opening 46
- Cardinals Running Back James Conner is Injury reserve
Cardinals vs Saints odds
Odds by Fanduel, updated Oct 9, 1:42 AM ETBet at Fanduel
How has the line moved?
| Captured | Saints spread | Total |
|---|---|---|
| Wed, Oct 7, 1:42 AM EDT | +2.5 | 46 |
| Wed, Oct 7, 11:18 AM EDT | +2.5 | 46.5 |
| Wed, Oct 7, 8:54 PM EDT | +2 | 46.5 |
| Thu, Oct 8, 6:30 AM EDT | +2 | 47 |
| Thu, Oct 8, 4:06 PM EDT | +2 | 47.5 |
| Fri, Oct 9, 1:42 AM EDT | +1.5 | 47.5 |
Saints spread
Total (over/under)
Cardinals vs Saints team comparison
| Cardinals | Saints | |
|---|---|---|
| 1-3 | Record | 1-3 |
| 21.8 | Points per game | 26.3 |
| 29.3 | Opponent points/game | 32.0 |
| -7.5 | Points differential | -5.8 |
| 0 | Head-to-head wins | 0 |
Injuries on both sides
| Team | Player | Pos | Status | Injury | Updated |
|---|---|---|---|---|---|
 Cardinals | James Conner | Running Back | Injury reserve | Foot | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Tip Reiman | Tight End | Out 4+ games | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Joey Blount | Safety | Injury reserve | Neck | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Zachary Carter | Defensive Tackle | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Kaleb Proctor | Defensive Tackle | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Chase Bisontis | Guard | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Trey Benson | Running Back | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Jameson Geers | Tight End | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Dadrion Taylor-Demerson | Safety | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Isaiah Adams | Guard | May play | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Garrett Williams | Cornerback | May play | Achilles | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Carson Beck | Quarterback | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Andrew Billings | Defensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Reggie Virgil | Wide Receiver | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Kitan Crawford | Safety | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Jack Gibbens | Linebacker | May play | Shoulder | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Roy Lopez | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Max Melton | Cornerback | May play | Toe | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Isaac Seumalo | Guard | May play | Shoulder | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Cody Simon | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Josh Fryar | Offensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Will Johnson | Cornerback | Injury reserve | Neck | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Hjalte Froholdt | Center | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Walter Nolen III | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Mack Wilson Sr. | Linebacker | May play | Thumb | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Josh Sweat | Linebacker | May play | Groin | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Cameron Robertson | Linebacker | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Starling Thomas V | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Andrew Wingard | Safety | May play | Knee | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Hunter Long | Tight End | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Paris Johnson Jr. | Offensive Tackle | Injury reserve | Biceps | Wed, Oct 7, 8:15 PM EDT |
| Cardinals | Jeremiyah Love | Running Back | May play | Ankle | Wed, Oct 7, 8:15 PM EDT |
 Saints | Mason Tipton | Wide Receiver | Out 4+ games | Leg | Wed, Oct 7, 8:15 PM EDT |
| Saints | Nick Saldiveri | Offensive Tackle | Out 4+ games | Knee | Wed, Oct 7, 8:15 PM EDT |
| Saints | Bryan Bresee | Defensive Tackle | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Saints | Cameron Jordan | Defensive End | May play | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Saints | Dillon Radunz | Guard | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| Saints | Jordyn Tyson | Wide Receiver | Injury reserve | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Saints | Ty Chandler | Running Back | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Saints | Oscar Delp | Tight End | May play | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Saints | Jaylan Ford | Linebacker | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Saints | Alvin Kamara | Running Back | May play | Back | Wed, Oct 7, 8:15 PM EDT |
| Saints | David Long Jr. | Cornerback | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Saints | Moliki Matavao | Tight End | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Saints | Lorenzo Styles Jr. | Safety | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| Saints | Rejzohn Wright | Cornerback | Injury reserve | Hip | Wed, Oct 7, 8:15 PM EDT |
| Saints | Khristian Boyd | Defensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Saints | Mason Murphy | Offensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Saints | John Ridgeway III | Defensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Saints | Zach Wilson | Quarterback | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| Saints | Juwan Johnson | Tight End | May play | Illness | Wed, Oct 7, 8:15 PM EDT |
| Saints | Isaiah Stalbird | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Saints | Zach Wood | Long Snapper | Injury reserve | Calf | Wed, Oct 7, 8:15 PM EDT |
| Saints | Chris Olave | Wide Receiver | May play | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Saints | Chase Young | Defensive End | May play | Calf | Wed, Oct 7, 8:15 PM EDT |
| Saints | Christen Miller | Defensive Tackle | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| Saints | Kendre Miller | Running Back | May play | Illness | Wed, Oct 7, 8:15 PM EDT |
| Saints | Decamerion Richardson | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Saints | Martin Emerson Jr. | Cornerback | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Saints | Kelvin Banks Jr. | Offensive Tackle | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Saints | Travis Etienne Jr. | Running Back | Injury reserve | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Saints | Barion Brown | Wide Receiver | May play | Brown recorded one carry for a… | Wed, Oct 7, 8:15 PM EDT |
| Saints | Jonas Sanker | Safety | May play | Knee | Wed, Oct 7, 8:15 PM EDT |
| Saints | Nathan Shepherd | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Saints | Treyton Welch | Tight End | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Saints | Tyree Wilson | Defensive End | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Saints | Pete Werner | Linebacker | May play | Neck | Wed, Oct 7, 8:15 PM EDT |
| Saints | Anfernee Jennings | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Saints | Noah Fant | Tight End | May play | Abdomen | Wed, Oct 7, 8:15 PM EDT |
| Saints | Julian Blackmon | Safety | May play | Shoulder | Wed, Oct 7, 8:15 PM EDT |
| Saints | Kaden Elliss | Linebacker | May play | Calf | Wed, Oct 7, 8:15 PM EDT |
| Saints | Carl Granderson | Defensive End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Saints | Davon Godchaux | Defensive Tackle | May play | Groin | Wed, Oct 7, 8:15 PM EDT |
| Saints | Tyler Shough | Quarterback | May play | Foot | Wed, Oct 7, 8:15 PM EDT |
Consensus Bets on this game
No consensus data yet for Cardinals at Saints. Check back closer to game time.
Frequently asked questions
Who is favoured in Cardinals vs Saints on Sunday, December 27?
Arizona Cardinals are favoured by 1.5 points (-1.5)
What is the spread for Cardinals vs Saints on Sunday, December 27?
Saints +1.5, Cardinals -1.5. Opened at +2.5 for Saints
What time is Cardinals vs Saints on Sunday, December 27?
Sunday, December 27, 2026 at 1:00 PM EST, Caesars Superdome, New Orleans, LA
What is Cardinals vs Saints head-to-head record?
Cardinals 0, Saints 0 in recent games