NFL · Week 15
49ers vs Chargers Betting Odds – Week 15
Thursday, December 17, 2026 · 8:15 PM EST · SoFi Stadium, Los Angeles, CA
Odds by Fanduel, updated Oct 9, 1:40 AM ET
- Los Angeles Chargers are favored by 3 points at -360, Thursday, December 17 at 8:15 PM EST
- Expected total is 44.5 points, up from the opening 43
- 49ers Fullback Kyle Juszczyk is Out
49ers vs Chargers odds
Odds by Fanduel, updated Oct 9, 1:40 AM ETBet at Fanduel
How has the line moved?
| Captured | Chargers spread | Total |
|---|---|---|
| Wed, Oct 7, 1:40 AM EDT | -3.5 | 43 |
| Wed, Oct 7, 11:16 AM EDT | -3.5 | 43.5 |
| Wed, Oct 7, 8:52 PM EDT | -3 | 44 |
| Thu, Oct 8, 6:28 AM EDT | -3.5 | 43.5 |
| Thu, Oct 8, 4:04 PM EDT | -3 | 44 |
| Fri, Oct 9, 1:40 AM EDT | -3 | 44.5 |
Chargers spread
Total (over/under)
49ers vs Chargers team comparison
| 49ers | Chargers | |
|---|---|---|
| 4-0 | Record | 0-4 |
| 30.5 | Points per game | 16.8 |
| 16.0 | Opponent points/game | 26.5 |
| +14.5 | Points differential | -9.8 |
| 0 | Head-to-head wins | 0 |
Injuries on both sides
| Team | Player | Pos | Status | Injury | Updated |
|---|---|---|---|---|---|
 49ers | Isaac Guerendo | Running Back | Out 4+ games | Pectoral | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Brandon Aiyuk | Wide Receiver | Reserve | Head | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Christian Kirk | Wide Receiver | Injury reserve | Calf | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Mykel Williams | Defensive End | Out 4+ games | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Ricky Pearsall | Wide Receiver | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Andrew Farmer II | Defensive End | Injury reserve | Back | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Darrick Forrest | Safety | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Mikail Kamara | Defensive End | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Sam Okuayinonu | Defensive Tackle | Injury reserve | Foot | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Brett Toth | Center | Injury reserve | Concussion | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Nate Hobbs | Cornerback | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Nick Martin | Linebacker | Injury reserve | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Austen Pleasants | Offensive Tackle | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Nick Zakelj | Offensive Tackle | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Alfred Collins | Defensive Tackle | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Tatum Bethune | Linebacker | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Enrique Cruz Jr. | Offensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jordan James | Running Back | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Ephesians Prysock | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Kurtis Rourke | Quarterback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jordan Watkins | Wide Receiver | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| 49ers | De'Zhaun Stribling | Wide Receiver | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jake Tonges | Tight End | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Kyle Juszczyk | Fullback | Out | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Khalid Kareem | Defensive End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| 49ers | George Kittle | Tight End | May play | Achilles | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Eddy Pineiro | Place Kicker | May play | Illness | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Keion White | Defensive End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Kaelon Black | Running Back | May play | Illness | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Romello Height | Defensive End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jack Jones | Cornerback | May play | Foot | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Demarcus Robinson | Wide Receiver | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Mike Evans | Wide Receiver | May play | Ribs | Wed, Oct 7, 8:15 PM EDT |
| 49ers | James Thompson Jr. | Defensive Tackle | Likely out | doubtful | Wed, Oct 7, 8:15 PM EDT |
| 49ers | C.J. West | Defensive Tackle | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Nick Bosa | Defensive End | Likely out | doubtful | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Dre Greenlaw | Linebacker | May play | Quadriceps | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Gracen Halton | Defensive Tackle | May play | Ankle | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Trent Williams | Offensive Tackle | May play | Neck | Wed, Oct 7, 8:15 PM EDT |
| 49ers | KhaDarel Hodge | Wide Receiver | May play | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jaden Dugger | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Marques Sigle | Safety | Out | out | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Upton Stout | Cornerback | May play | Shoulder | Wed, Oct 7, 8:15 PM EDT |
 Chargers | Isaiah World | Offensive Tackle | Out 4+ games | nfi-r | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Tyler Biadasz | Center | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Scott Matlock | Fullback | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Denzel Perryman | Linebacker | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Branson Taylor | Guard | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Deane Leonard | Cornerback | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Alex Harkey | Guard | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Chargers | RJ Mickens | Safety | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Trevor Penning | Guard | May play | Head | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Logan Taylor | Guard | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Ladd McConkey | Wide Receiver | May play | Foot | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Elijah Molden | Cornerback | May play | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Chargers | KeAndre Lambert-Smith | Wide Receiver | Injury reserve | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Derius Davis | Wide Receiver | May play | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Trey Pipkins III | Offensive Tackle | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Teair Tart | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Dalvin Tomlinson | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Isas Waxter | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Derwin James Jr. | Safety | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | David Njoku | Tight End | Injury reserve | Fibula | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Kayode Awosika | Guard | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Charlie Kolar | Tight End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Brenen Thompson | Wide Receiver | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Rodney Shelley | Cornerback | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Rashawn Slater | Offensive Tackle | Out | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Cole Strange | Guard | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Tuli Tuipulotu | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Trey Lance | Quarterback | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | DJ Uiagalelei | Quarterback | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Donte Jackson | Cornerback | May play | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Justin Eboigbe | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Keaton Mitchell | Running Back | May play | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Joe Alt | Offensive Tackle | May play | Neck | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Quentin Johnston | Wide Receiver | May play | Johnston was limited at Wednes… | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Cam Hart | Cornerback | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chargers | Alec Ingold | Fullback | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
Consensus Bets on this game
No consensus data yet for 49ers at Chargers. Check back closer to game time.
Frequently asked questions
Who is favoured in 49ers vs Chargers on Thursday, December 17?
Los Angeles Chargers are favoured by 3 points (-3)
What is the spread for 49ers vs Chargers on Thursday, December 17?
Chargers -3, 49ers +3. Opened at -3.5 for Chargers
What time is 49ers vs Chargers on Thursday, December 17?
Thursday, December 17, 2026 at 8:15 PM EST, SoFi Stadium, Los Angeles, CA
What is 49ers vs Chargers head-to-head record?
49ers 0, Chargers 0 in recent games