NFL · Week 5
49ers vs Seahawks Betting Odds – Week 5
Sunday, October 11, 2026 · 4:25 PM EDT · Lumen Field, Seattle, WA
Odds by Fanduel, updated Oct 9, 2:27 AM ET
- Seattle Seahawks are favored by 1.5 points at -183, Sunday, October 11 at 4:25 PM EDT
- Expected total is 46.5 points, up from the opening 46
- 49ers Fullback Kyle Juszczyk is Out
49ers vs Seahawks odds
Odds by Fanduel, updated Oct 9, 2:27 AM ETBet at Fanduel
How has the line moved?
| Captured | Seahawks spread | Total |
|---|---|---|
| Mon, Oct 5, 4:25 PM EDT | -2.5 | 46 |
| Tue, Oct 6, 8:50 AM EDT | -2.5 | 46 |
| Wed, Oct 7, 1:16 AM EDT | -2 | 46 |
| Wed, Oct 7, 5:42 PM EDT | -2 | 46.5 |
| Thu, Oct 8, 10:08 AM EDT | -1.5 | 46.5 |
| Fri, Oct 9, 2:34 AM EDT | -1.5 | 46.5 |
Seahawks spread
Total (over/under)
49ers vs Seahawks team comparison
| 49ers | Seahawks | |
|---|---|---|
| 4-0 | Record | 3-1 |
| 30.5 | Points per game | 26.3 |
| 16.0 | Opponent points/game | 18.3 |
| +14.5 | Points differential | +8.0 |
| 0 | Head-to-head wins | 0 |
Injuries on both sides
| Team | Player | Pos | Status | Injury | Updated |
|---|---|---|---|---|---|
 49ers | Isaac Guerendo | Running Back | Out 4+ games | Pectoral | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Brandon Aiyuk | Wide Receiver | Reserve | Head | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Christian Kirk | Wide Receiver | Injury reserve | Calf | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Mykel Williams | Defensive End | Out 4+ games | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Ricky Pearsall | Wide Receiver | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Andrew Farmer II | Defensive End | Injury reserve | Back | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Darrick Forrest | Safety | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Mikail Kamara | Defensive End | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Sam Okuayinonu | Defensive Tackle | Injury reserve | Foot | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Brett Toth | Center | Injury reserve | Concussion | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Nate Hobbs | Cornerback | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Nick Martin | Linebacker | Injury reserve | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Austen Pleasants | Offensive Tackle | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Nick Zakelj | Offensive Tackle | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Alfred Collins | Defensive Tackle | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Tatum Bethune | Linebacker | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Enrique Cruz Jr. | Offensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jordan James | Running Back | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Ephesians Prysock | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Kurtis Rourke | Quarterback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jordan Watkins | Wide Receiver | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| 49ers | De'Zhaun Stribling | Wide Receiver | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jake Tonges | Tight End | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Kyle Juszczyk | Fullback | Out | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Khalid Kareem | Defensive End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| 49ers | George Kittle | Tight End | May play | Achilles | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Eddy Pineiro | Place Kicker | May play | Illness | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Keion White | Defensive End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Kaelon Black | Running Back | May play | Illness | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Romello Height | Defensive End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jack Jones | Cornerback | May play | Foot | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Demarcus Robinson | Wide Receiver | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Mike Evans | Wide Receiver | May play | Ribs | Wed, Oct 7, 8:15 PM EDT |
| 49ers | James Thompson Jr. | Defensive Tackle | Likely out | doubtful | Wed, Oct 7, 8:15 PM EDT |
| 49ers | C.J. West | Defensive Tackle | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Nick Bosa | Defensive End | Likely out | doubtful | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Dre Greenlaw | Linebacker | May play | Quadriceps | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Gracen Halton | Defensive Tackle | May play | Ankle | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Trent Williams | Offensive Tackle | May play | Neck | Wed, Oct 7, 8:15 PM EDT |
| 49ers | KhaDarel Hodge | Wide Receiver | May play | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jaden Dugger | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Marques Sigle | Safety | Out | out | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Upton Stout | Cornerback | May play | Shoulder | Wed, Oct 7, 8:15 PM EDT |
 Seahawks | Zach Charbonnet | Running Back | Out 4+ games | Knee | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Nick Emmanwori | Safety | May play | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Robbie Ouzts | Fullback | Injury reserve | Neck | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Jake Bobo | Wide Receiver | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Irv Charles | Wide Receiver | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Bud Clark | Safety | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Tory Horton | Wide Receiver | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Ty Okada | Safety | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Mason Richman | Guard | Injury reserve | Leg | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Nick Kallerup | Tight End | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Jalen Milroe | Quarterback | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Mike Morris | Defensive End | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Beau Stephens | Guard | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Sam Darnold | Quarterback | May play | Glute | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Anthony Bradford | Guard | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Josh Jones | Guard | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Cooper Kupp | Wide Receiver | May play | Back | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Montorie Foster Jr. | Wide Receiver | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Connor O'Toole | Linebacker | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Brandon Pili | Defensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Jadarian Price | Running Back | Injury reserve | Chest | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | George Holani | Running Back | May play | Ribs | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Ernest Jones IV | Linebacker | May play | Neck | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Brady Russell | Fullback | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Julian Love | Safety | May play | Calf | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Avery Smith | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Jarran Reed | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Grey Zabel | Guard | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Chazz Surratt | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Leonard Williams | Defensive Tackle | May play | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Tyrice Knight | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Nehemiah Pritchett | Cornerback | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
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Frequently asked questions
Who is favoured in 49ers vs Seahawks on Sunday, October 11?
Seattle Seahawks are favoured by 1.5 points (-1.5)
What is the spread for 49ers vs Seahawks on Sunday, October 11?
Seahawks -1.5, 49ers +1.5. Opened at -2.5 for Seahawks
What time is 49ers vs Seahawks on Sunday, October 11?
Sunday, October 11, 2026 at 4:25 PM EDT, Lumen Field, Seattle, WA
What is 49ers vs Seahawks head-to-head record?
49ers 0, Seahawks 0 in recent games