NFL · Week 12
Seahawks vs 49ers Betting Odds – Week 12
Saturday, November 28, 2026 · 7:00 PM EST · San Francisco Arena, San Francisco, CA
Updated Oct 29, 6:38 AM ET
Week 12
Saturday, November 28
7:00 PM EST
@ San Francisco Arena, San Francisco, CA
- Seattle Seahawks visit San Francisco 49ers on Saturday, November 28 at 7:00 PM EST
- No Fanduel odds are posted yet for this game
- 49ers Fullback Kyle Juszczyk is Out
Seahawks vs 49ers team comparison
| Seahawks | 49ers | |
|---|---|---|
| 4-3 | Record | 6-1 |
| 24.0 | Points per game | 28.1 |
| 17.9 | Opponent points/game | 19.9 |
| +6.1 | Points differential | +8.3 |
| 0 | Head-to-head wins | 1 |
Injuries on both sides
| Team | Player | Pos | Status | Injury | Updated |
|---|---|---|---|---|---|
 Seahawks | Zach Charbonnet | Running Back | Out 4+ games | Knee | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Nick Emmanwori | Safety | May play | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Robbie Ouzts | Fullback | Injury reserve | Neck | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Jake Bobo | Wide Receiver | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Irv Charles | Wide Receiver | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Bud Clark | Safety | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Tory Horton | Wide Receiver | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Ty Okada | Safety | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Mason Richman | Guard | Injury reserve | Leg | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Nick Kallerup | Tight End | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Jalen Milroe | Quarterback | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Mike Morris | Defensive End | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Beau Stephens | Guard | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Sam Darnold | Quarterback | May play | Glute | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Anthony Bradford | Guard | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Josh Jones | Guard | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Cooper Kupp | Wide Receiver | May play | Back | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Montorie Foster Jr. | Wide Receiver | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Connor O'Toole | Linebacker | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Brandon Pili | Defensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Jadarian Price | Running Back | Injury reserve | Chest | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | George Holani | Running Back | May play | Ribs | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Ernest Jones IV | Linebacker | May play | Neck | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Brady Russell | Fullback | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Julian Love | Safety | May play | Calf | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Avery Smith | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Jarran Reed | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Grey Zabel | Guard | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Chazz Surratt | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Leonard Williams | Defensive Tackle | May play | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Tyrice Knight | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Seahawks | Nehemiah Pritchett | Cornerback | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
 49ers | Isaac Guerendo | Running Back | Out 4+ games | Pectoral | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Brandon Aiyuk | Wide Receiver | Reserve | Head | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Christian Kirk | Wide Receiver | Injury reserve | Calf | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Mykel Williams | Defensive End | Out 4+ games | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Ricky Pearsall | Wide Receiver | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Andrew Farmer II | Defensive End | Injury reserve | Back | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Darrick Forrest | Safety | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Mikail Kamara | Defensive End | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Sam Okuayinonu | Defensive Tackle | Injury reserve | Foot | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Brett Toth | Center | Injury reserve | Concussion | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Nate Hobbs | Cornerback | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Nick Martin | Linebacker | Injury reserve | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Austen Pleasants | Offensive Tackle | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Nick Zakelj | Offensive Tackle | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Alfred Collins | Defensive Tackle | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Tatum Bethune | Linebacker | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Enrique Cruz Jr. | Offensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jordan James | Running Back | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Ephesians Prysock | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Kurtis Rourke | Quarterback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jordan Watkins | Wide Receiver | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| 49ers | De'Zhaun Stribling | Wide Receiver | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jake Tonges | Tight End | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Kyle Juszczyk | Fullback | Out | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Khalid Kareem | Defensive End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| 49ers | George Kittle | Tight End | May play | Achilles | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Eddy Pineiro | Place Kicker | May play | Illness | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Keion White | Defensive End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Kaelon Black | Running Back | May play | Illness | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Romello Height | Defensive End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jack Jones | Cornerback | May play | Foot | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Demarcus Robinson | Wide Receiver | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Mike Evans | Wide Receiver | May play | Ribs | Wed, Oct 7, 8:15 PM EDT |
| 49ers | James Thompson Jr. | Defensive Tackle | Likely out | doubtful | Wed, Oct 7, 8:15 PM EDT |
| 49ers | C.J. West | Defensive Tackle | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Nick Bosa | Defensive End | Likely out | doubtful | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Dre Greenlaw | Linebacker | May play | Quadriceps | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Gracen Halton | Defensive Tackle | May play | Ankle | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Trent Williams | Offensive Tackle | May play | Neck | Wed, Oct 7, 8:15 PM EDT |
| 49ers | KhaDarel Hodge | Wide Receiver | May play | Knee | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Jaden Dugger | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Marques Sigle | Safety | Out | out | Wed, Oct 7, 8:15 PM EDT |
| 49ers | Upton Stout | Cornerback | May play | Shoulder | Wed, Oct 7, 8:15 PM EDT |
Consensus Bets on this game
No consensus data yet for Seahawks at 49ers. Check back closer to game time.
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Frequently asked questions
Who is favored in Seahawks vs 49ers on Saturday, November 28?
No line is posted yet
What is the spread for Seahawks vs 49ers on Saturday, November 28?
No spread is posted yet
What time is Seahawks vs 49ers on Saturday, November 28?
Saturday, November 28, 2026 at 7:00 PM EST, San Francisco Arena, San Francisco, CA
What is Seahawks vs 49ers head-to-head record?
Seahawks 0, 49ers 1 in recent games