NFL · Week 12
Chiefs vs Bills Betting Odds – Week 12
Thursday, November 26, 2026 · 8:20 PM EST · Highmark Stadium, Buffalo, NY
Odds by Fanduel, updated Oct 9, 2:43 AM ET
- Buffalo Bills are favored by 5.5 points at -1900, Thursday, November 26 at 8:20 PM EST
- Expected total is 46 points, up from the opening 44.5
- Chiefs Wide Receiver Tyquan Thornton is Out
Chiefs vs Bills odds
Odds by Fanduel, updated Oct 9, 2:43 AM ETBet at Fanduel
How has the line moved?
| Captured | Bills spread | Total |
|---|---|---|
| Wed, Oct 7, 2:45 AM EDT | -4 | 44.5 |
| Wed, Oct 7, 12:21 PM EDT | -4.5 | 45 |
| Wed, Oct 7, 9:57 PM EDT | -4.5 | 45 |
| Thu, Oct 8, 7:33 AM EDT | -5 | 45 |
| Thu, Oct 8, 5:09 PM EDT | -5 | 45.5 |
| Fri, Oct 9, 2:45 AM EDT | -5.5 | 46 |
Bills spread
Total (over/under)
Chiefs vs Bills team comparison
| Chiefs | Bills | |
|---|---|---|
| 4-0 | Record | 3-1 |
| 29.5 | Points per game | 31.8 |
| 19.3 | Opponent points/game | 26.8 |
| +10.3 | Points differential | +5.0 |
| 0 | Head-to-head wins | 0 |
Injuries on both sides
| Team | Player | Pos | Status | Injury | Updated |
|---|---|---|---|---|---|
 Chiefs | Omarr Norman-Lott | Defensive Tackle | Out 4+ games | Knee | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Ethan Downs | Linebacker | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | John Michael Gyllenborg | Tight End | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Jeff Caldwell | Wide Receiver | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Jimmy Holiday | Wide Receiver | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Josh Simmons | Offensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Matt Waletzko | Offensive Tackle | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Chamarri Conner | Safety | May play | Knee | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Bryson Eason | Defensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Garrett Nussmeier | Quarterback | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Diego Pounds | Offensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Jack Pyburn | Linebacker | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Jared Wiley | Tight End | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Mansoor Delane | Cornerback | May play | Shoulder | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Cooper McDonald | Linebacker | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Chris Jones | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Felix Anudike-Uzomah | Defensive End | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | L'Jarius Sneed | Cornerback | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Tyreke Smith | Defensive End | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Jadon Canady | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Rashee Rice | Wide Receiver | May play | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Chiefs | Tyquan Thornton | Wide Receiver | Out | Ankle | Wed, Oct 7, 8:15 PM EDT |
 Bills | Tyrell Shavers | Wide Receiver | Out 4+ games | out | Wed, Oct 7, 8:15 PM EDT |
| Bills | Dorian Strong | Cornerback | Out 4+ games | nfi-r | Wed, Oct 7, 8:15 PM EDT |
| Bills | Ty Johnson | Running Back | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Bills | Phidarian Mathis | Defensive Tackle | Suspended | reserve-sus | Wed, Oct 7, 8:15 PM EDT |
| Bills | Zane Durant | Defensive Tackle | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| Bills | T.J. Sanders | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Bills | Skyler Bell | Wide Receiver | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Bills | Jude Bowry | Offensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Bills | Mike Danna | Defensive End | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Bills | Jalon Kilgore | Safety | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Bills | Ar'maj Reed-Adams | Guard | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Bills | Terrel Bernard | Linebacker | May play | Calf | Wed, Oct 7, 8:15 PM EDT |
| Bills | Cole Bishop | Safety | May play | Groin | Wed, Oct 7, 8:15 PM EDT |
| Bills | Ed Oliver | Defensive Tackle | May play | Knee | Wed, Oct 7, 8:15 PM EDT |
| Bills | DJ Moore | Wide Receiver | May play | Shoulder | Wed, Oct 7, 8:15 PM EDT |
| Bills | Keon Coleman | Wide Receiver | May play | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Bills | Jordan Hancock | Cornerback | Injury reserve | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Bills | Christian Benford | Cornerback | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Bills | Josh Allen | Quarterback | May play | Knee | Wed, Oct 7, 8:15 PM EDT |
| Bills | Joe Andreessen | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Bills | Damar Hamlin | Safety | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Bills | Deone Walker | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Bills | Sam Franklin Jr. | Safety | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Bills | Ray Davis | Running Back | May play | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Bills | Te'Cory Couch | Cornerback | May play | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Bills | Dee Alford | Cornerback | May play | Ankle | Wed, Oct 7, 8:15 PM EDT |
Consensus Bets on this game
No consensus data yet for Chiefs at Bills. Check back closer to game time.
Frequently asked questions
Who is favoured in Chiefs vs Bills on Thursday, November 26?
Buffalo Bills are favoured by 5.5 points (-5.5)
What is the spread for Chiefs vs Bills on Thursday, November 26?
Bills -5.5, Chiefs +5.5. Opened at -4 for Bills
What time is Chiefs vs Bills on Thursday, November 26?
Thursday, November 26, 2026 at 8:20 PM EST, Highmark Stadium, Buffalo, NY
What is Chiefs vs Bills head-to-head record?
Chiefs 0, Bills 0 in recent games