NFL · Week 4
Lions vs Panthers Betting Odds – Week 4
Last game: Sunday, October 4, 2026 · 8:20 PM EDT · Bank of America Stadium, Carolina, NC
Odds by Fanduel, updated Oct 9, 5:22 AM ET
Week 4
Sunday, October 4
8:20 PM EDT
@ Bank of America Stadium, Carolina, NC
Final: Lions 26, Panthers 32
- Detroit Lions are favored by 3.5 points at -510
- Expected total is 48 points, down from the opening 49
- Lions Offensive Tackle Giovanni Manu is Out 4+ games
Lions vs Panthers odds
Odds by Fanduel, updated Oct 9, 5:22 AM ETBet at Fanduel
How has the line moved?
| Captured | Panthers spread | Total |
|---|---|---|
| Mon, Sep 28, 8:20 PM EDT | +2.5 | 49 |
| Wed, Sep 30, 10:09 PM EDT | +2.5 | 48.5 |
| Fri, Oct 2, 11:58 PM EDT | +2.5 | 48.5 |
| Mon, Oct 5, 1:47 AM EDT | +3.5 | 48.5 |
| Wed, Oct 7, 3:36 AM EDT | +3 | 48 |
| Fri, Oct 9, 5:25 AM EDT | +3.5 | 48 |
Panthers spread
Total (over/under)
Lions vs Panthers team comparison
| Lions | Panthers | |
|---|---|---|
| 2-2 | Record | 2-2 |
| 29.8 | Points per game | 30.3 |
| 31.8 | Opponent points/game | 27.3 |
| -2.0 | Points differential | +3.0 |
| 0 | Head-to-head wins | 1 |
Injuries on both sides
| Team | Player | Pos | Status | Injury | Updated |
|---|---|---|---|---|---|
 Lions | Giovanni Manu | Offensive Tackle | Out 4+ games | Knee | Wed, Oct 7, 8:15 PM EDT |
| Lions | Brian Branch | Safety | Out 4+ games | Achilles | Wed, Oct 7, 8:15 PM EDT |
| Lions | Kerby Joseph | Safety | Out 4+ games | Knee | Wed, Oct 7, 8:15 PM EDT |
| Lions | Kendrick Law | Wide Receiver | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Lions | Cade Mays | Center | Injury reserve | Wrist | Wed, Oct 7, 8:15 PM EDT |
| Lions | Isiah Pacheco | Running Back | Injury reserve | Back | Wed, Oct 7, 8:15 PM EDT |
| Lions | Payton Turner | Defensive End | Injury reserve | ir | Wed, Oct 7, 8:15 PM EDT |
| Lions | Damone Clark | Linebacker | Injury reserve | Undisclosed | Wed, Oct 7, 8:15 PM EDT |
| Lions | Christian Izien | Safety | May play | out | Wed, Oct 7, 8:15 PM EDT |
| Lions | Ahmed Hassanein | Defensive End | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | Ennis Rakestraw Jr. | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | Jimmy Rolder | Linebacker | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | Mekhi Wingo | Defensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | Christian Mahogany | Guard | May play | Hip | Wed, Oct 7, 8:15 PM EDT |
| Lions | Blake Miller | Offensive Tackle | May play | Knee | Wed, Oct 7, 8:15 PM EDT |
| Lions | Juice Scruggs | Guard | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Lions | D.J. Reed | Cornerback | May play | Ribs | Wed, Oct 7, 8:15 PM EDT |
| Lions | Keith Abney II | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | Avonte Maddox | Cornerback | Injury reserve | Foot | Wed, Oct 7, 8:15 PM EDT |
| Lions | Ben Bartch | Guard | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Lions | Thomas Harper | Safety | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Lions | Tate Ratledge | Guard | May play | Elbow | Wed, Oct 7, 8:15 PM EDT |
| Lions | Tyler Conklin | Tight End | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | Bishop Fitzgerald | Safety | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | Devin White | Linebacker | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Lions | DJ Wonnum | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Lions | Rock Ya-Sin | Cornerback | Likely out | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Lions | Tyleik Williams | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
 Panthers | Ikem Ekwonu | Offensive Tackle | Out 4+ games | Knee | Wed, Oct 7, 8:15 PM EDT |
| Panthers | Taylor Moton | Offensive Tackle | Out 4+ games | Illness | Wed, Oct 7, 8:15 PM EDT |
| Panthers | Tershawn Wharton | Defensive Tackle | Out 4+ games | Neck | Wed, Oct 7, 8:15 PM EDT |
| Panthers | Nic Scourton | Linebacker | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Panthers | Chris Brazzell II | Wide Receiver | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Panthers | Brady Christensen | Guard | Injury reserve | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Panthers | Trevor Etienne | Running Back | Injury reserve | Ankle | Wed, Oct 7, 8:15 PM EDT |
| Panthers | Bam Martin-Scott | Linebacker | Injury reserve | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Panthers | Patrick Jones II | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Panthers | Cam Jackson | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Panthers | Haynes King | Quarterback | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| Panthers | John Metchie III | Wide Receiver | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| Panthers | Albert Reese IV | Offensive Tackle | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Panthers | Ja'Tavion Sanders | Tight End | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Panthers | Zakee Wheatley | Safety | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Panthers | Jalen Coker | Wide Receiver | May play | Quadriceps | Wed, Oct 7, 8:15 PM EDT |
| Panthers | Bobby Brown III | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Panthers | Tyrel Dodson | Linebacker | Not playing | Coach's decision | Wed, Oct 7, 8:15 PM EDT |
| Panthers | Chau Smith-Wade | Cornerback | Not playing | inactive | Wed, Oct 7, 8:15 PM EDT |
| Panthers | Nick Scott | Safety | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Panthers | Claudin Cherelus | Linebacker | Injury reserve | Shoulder | Wed, Oct 7, 8:15 PM EDT |
| Panthers | Jonathon Brooks | Running Back | Injury reserve | Brooks is expected to undergo … | Wed, Oct 7, 8:15 PM EDT |
| Panthers | Trevis Gipson | Linebacker | May play | Concussion | Wed, Oct 7, 8:15 PM EDT |
| Panthers | Devin Lloyd | Linebacker | May play | Calf | Wed, Oct 7, 8:15 PM EDT |
| Panthers | Jaelan Phillips | Linebacker | May play | Hamstring | Wed, Oct 7, 8:15 PM EDT |
| Panthers | Xavier Legette | Wide Receiver | Injury reserve | Knee | Wed, Oct 7, 8:15 PM EDT |
| Panthers | Mike Jackson | Cornerback | Injury reserve | Groin | Wed, Oct 7, 8:15 PM EDT |
| Panthers | Damien Lewis | Guard | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Panthers | Jaycee Horn | Cornerback | Injury reserve | Quadriceps | Wed, Oct 7, 8:15 PM EDT |
| Panthers | Monroe Freeling | Offensive Tackle | May play | Knee | Wed, Oct 7, 8:15 PM EDT |
| Panthers | Princely Umanmielen | Linebacker | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
| Panthers | Lee Hunter | Defensive Tackle | May play | questionable | Wed, Oct 7, 8:15 PM EDT |
Consensus Bets on this game
No consensus data yet for Lions at Panthers. Check back closer to game time.
Previous games
Frequently asked questions
Who is favoured in Lions vs Panthers?
Detroit Lions were favoured by 3.5 points (-3.5)
What is the spread for Lions vs Panthers?
Panthers +3.5, Lions -3.5. Opened at +2.5 for Panthers
What time is Lions vs Panthers?
No game is currently scheduled
What is Lions vs Panthers head-to-head record?
Lions 0, Panthers 1 in recent games